Opaleye Management Inc.
CIK 1595855 · Holdings on Mar 31, 2024 · First reported May 29, 2024
Top ten holdings
Q1 2024- OCUL13.19%
- HROW11.30%
- TGTX7.56%
- KROS5.30%
- RYTM4.86%
- 14888U1013.49%
- ARVN2.97%
- IOVA2.90%
- JSPR2.79%
- EWTX2.64%
Share classes counted separately57.00%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- OCULWeight increased · +5.99 pp7.20% → 13.19%Shares +583.14K (+9.61%)
- SLRNWeight decreased · -5.90 pp8.22% → 2.32%Shares -2.57M (-61.89%)
- RYTMWeight decreased · -2.60 pp7.46% → 4.86%Shares -95.00K (-15.57%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 30
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | OCULOCULAR THERAPEUTIX INC View history and evidence | $60.54M | 13.19% | 6.65M shares | 7.20% → 13.19%+5.99 pp +583.14K (+9.61%) | Added | ↗▾ |
| 02 | HROWHARROW INC View history and evidence | $51.87M | 11.30% | 3.92M shares | 11.38% → 11.30%-0.08 pp +100.60K (+2.63%) | Added | ↗▾ |
| 03 | TGTXTG THERAPEUTICS INC View history and evidence | $34.68M | 7.56% | 2.28M shares | 10.06% → 7.56%-2.50 pp +65.00K (+2.93%) | Added | ↗▾ |
| 04 | KROSKEROS THERAPEUTICS INC View history and evidence | $24.33M | 5.30% | 367.50K shares | 3.78% → 5.30%+1.52 pp +10.00K (+2.80%) | Added | ↗▾ |
| 05 | RYTMRHYTHM PHARMACEUTICALS INC View history and evidence | $22.31M | 4.86% | 515.00K shares | 7.46% → 4.86%-2.60 pp -95.00K (-15.57%) | Reduced | ↗▾ |
| 06 | 14888U101CATALYST PHARMACEUTICALS INC View history and evidence | $16.01M | 3.49% | 1.00M shares | 5.70% → 3.49%-2.21 pp -252.84K (-20.11%) | Reduced | ↗▾ |
| 07 | ARVNARVINAS INC View history and evidence | $13.62M | 2.97% | 330.00K shares | 2.89% → 2.97%+0.08 pp +66.30K (+25.14%) | Added | ↗▾ |
| 08 | IOVAIOVANCE BIOTHERAPEUTICS INC View history and evidence | $13.29M | 2.90% | 897.00K shares | 1.94% → 2.90%+0.96 pp 0 (0.00%) | Unchanged | ↗▾ |
| 09 | JSPRJASPER THERAPEUTICS INCCOM NEW View history and evidence | $12.79M | 2.79% | 435.57K shares | Prior unavailable — | CUSIP change | ↗▾ |
| 10 | EWTXEDGEWISE THERAPEUTICS INC View history and evidence | $12.13M | 2.64% | 665.00K shares | 2.03% → 2.64%+0.61 pp -34.00K (-4.86%) | Reduced | ↗▾ |
Options overlay 0
No options reported this quarter.
Exited positions 7
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| IDYA IDEAYA BIOSCIENCES INC | Non-derivative | -311,500 | -$11.08M | SEC filing ↗ | SEC filing ↗ |
| BHVN BIOHAVEN LTD | Non-derivative | -200,000 | -$8.56M | SEC filing ↗ | SEC filing ↗ |
| ARQT ARCUTIS BIOTHERAPEUTICS INC | Non-derivative | -1,960,000 | -$6.33M | SEC filing ↗ | SEC filing ↗ |
3 / 7 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 1595855 · Period 2024-03-31
Data loaded 2026-09-23 · First reported 2024-05-29
Amendments and versions
{
"amendments_merged": [
{
"action": "REPLACE",
"accession": "0001493152-24-021780",
"cover_total": 458857062,
"filing_date": "2024-05-29",
"claimed_type": "RESTATEMENT",
"confidential": false,
"positions_added": 1,
"positions_restated": 2,
"positions_cancelled": 0
}
],
"prior_versions": [
{
"accession": "0001493152-24-019869",
"filing_date": "2024-05-15",
"confidential": false,
"cover_table_value_total_raw": 436932852
}
],
"cover_table_value": 458857062
}Research all 52 reported holdings.
This page includes 30 of 52 reported holdings. Sign in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.
- Download CSV
- Earlier quarters
- Advanced screening & filtering
- API & AI access
＋ New accounts get free API credits to explore data beyond ownership filings.
For AI agents & developers
The initial HTML of this page carries its exact data as script#portfolio-data (JSON): values, units, scope, preview limits and SEC sources. Read it directly, no script or API key needed; script#research-access says what needs an account. This page lists 30 of 52 current positions (options included); totals and weights use the complete filing.
Without an account: the last 3 years, with the row caps stated on the page. A free account opens all history on file on these pages and the CSV of what a page shows. Rows beyond the caps and bulk retrieval go through the authenticated API / MCP.
MCP https://api.akkrudata.ai/mcp
get_institutional_portfolio
{"cik":"1595855","quarter":"2024Q1","page_size":100}
get_institutional_manager_history
{"cik":"1595855","page_size":100}Connect to MCP with OAuth and follow the returned pagination. Credits and usage limits depend on the account.
- MCP endpoint
- https://api.akkrudata.ai/mcp
- API / MCP documentation
- /documents
- llms.txt
- /llms.txt
Sources, coverage & how to read this data
Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.