5AM Venture Management, LLC
CIK 1799883 · Holdings on Sep 30, 2025 · First reported Nov 14, 2025
Top ten holdings
Q3 2025- 83086J20013.94%
- TRDA9.04%
- PHVS7.29%
- CAMP6.45%
- CNTA6.05%
- VRDN5.82%
- ELVN5.79%
- EYPT5.48%
- DNTH5.26%
- TYRA4.81%
Share classes counted separately69.93%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- CAMPWeight increased · +4.82 pp1.63% → 6.45%Shares +2.94M (+100.45%)
- TRDAWeight decreased · -2.09 pp11.13% → 9.04%Shares -52.00K (-1.21%)
- 83086J200Weight decreased · -1.99 pp15.93% → 13.94%Shares -231.41K (-2.33%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 25
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | 83086J200SKYE BIOSCIENCE INCCOM NEW View history and evidence | $38.05M | 13.94% | 9.68M shares | 15.93% → 13.94%-1.99 pp -231.41K (-2.33%) | Reduced | ↗▾ |
| 02 | TRDAENTRADA THERAPEUTICS INC View history and evidence | $24.69M | 9.04% | 4.26M shares | 11.13% → 9.04%-2.09 pp -52.00K (-1.21%) | Reduced | ↗▾ |
| 03 | PHVSPHARVARIS NV View history and evidence | $19.90M | 7.29% | 797.60K shares | 5.40% → 7.29%+1.89 pp 0 (0.00%) | Unchanged | ↗▾ |
| 04 | CAMPCAMP4 THERAPEUTICS CORP View history and evidence | $17.61M | 6.45% | 5.87M shares | 1.63% → 6.45%+4.82 pp +2.94M (+100.45%) | Added | ↗▾ |
| 05 | CNTACENTESSA PHARMACEUTICALS-ADRSPONSORED ADS View history and evidence | $16.51M | 6.05% | 680.95K shares | 4.20% → 6.05%+1.85 pp -150.00K (-18.05%) | Reduced | ↗▾ |
| 06 | VRDNVIRIDIAN THERAPEUTICS INC View history and evidence | $15.90M | 5.82% | 736.60K shares | 3.96% → 5.82%+1.86 pp 0 (0.00%) | Unchanged | ↗▾ |
| 07 | ELVNENLIVEN THERAPEUTICS INC View history and evidence | $15.81M | 5.79% | 772.48K shares | 5.96% → 5.79%-0.17 pp 0 (0.00%) | Unchanged | ↗▾ |
| 08 | EYPTEYEPOINT INCCOM NEW View history and evidence | $14.95M | 5.48% | 1.05M shares | 3.80% → 5.48%+1.68 pp 0 (0.00%) | Unchanged | ↗▾ |
| 09 | DNTHDIANTHUS THERAPEUTICS INC View history and evidence | $14.36M | 5.26% | 365.05K shares | 7.05% → 5.26%-1.79 pp -619.67K (-62.93%) | Reduced | ↗▾ |
| 10 | TYRATYRA BIOSCIENCES INC View history and evidence | $13.14M | 4.81% | 939.30K shares | 3.46% → 4.81%+1.35 pp 0 (0.00%) | Unchanged | ↗▾ |
Options overlay 0
No options reported this quarter.
Exited positions 5
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| MLTX MOONLAKE IMMUNOTHERAPEUTICS | Non-derivative | -282,313 | -$13.33M | SEC filing ↗ | SEC filing ↗ |
| 929033108 VOR BIOPHARMA INC | Non-derivative | -6,361,723 | -$10.31M | SEC filing ↗ | SEC filing ↗ |
| VKTX VIKING THERAPEUTICS INC | Non-derivative | -189,593 | -$5.02M | SEC filing ↗ | SEC filing ↗ |
3 / 5 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 1799883 · Period 2025-09-30
Data loaded 2026-09-23 · First reported 2025-11-14
Amendments and versions
{
"amendments_merged": null,
"prior_versions": null,
"cover_table_value": 273045105
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