Paradigm Biocapital Advisors LP
CIK 1855655 · Holdings on Sep 30, 2025 · First reported Nov 14, 2025
Top ten holdings
Q3 2025- NUVL13.48%
- MRUS12.18%
- ACLX11.29%
- RVMD8.60%
- TARS4.69%
- PCVX4.03%
- ABVX3.93%
- GMAB3.46%
- AGIO3.18%
- CRNX3.14%
Share classes counted separately67.98%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- NUVLWeight decreased · -3.69 pp17.17% → 13.48%Shares 0 (0.00%)
- MRUSWeight increased · +2.56 pp9.62% → 12.18%Shares +91.82K (+2.14%)
- COGTWeight decreased · -1.83 pp3.17% → 1.34%Shares -7.20M (-69.51%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 27
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | NUVLNUVALENT INC-A View history and evidence | $455.70M | 13.48% | 5.27M shares | 17.17% → 13.48%-3.69 pp 0 (0.00%) | Unchanged | ↗▾ |
| 02 | MRUSMERUS NV View history and evidence | $411.79M | 12.18% | 4.37M shares | 9.62% → 12.18%+2.56 pp +91.82K (+2.14%) | Added | ↗▾ |
| 03 | ACLXARCELLX INCCOMMON STOCK View history and evidence | $381.68M | 11.29% | 4.65M shares | 13.07% → 11.29%-1.78 pp 0 (0.00%) | Unchanged | ↗▾ |
| 04 | RVMDREVOLUTION MEDICINES INC View history and evidence | $290.63M | 8.60% | 6.22M shares | 9.57% → 8.60%-0.97 pp +130.00K (+2.13%) | Added | ↗▾ |
| 05 | TARSTARSUS PHARMACEUTICALS INC View history and evidence | $158.42M | 4.69% | 2.67M shares | 5.15% → 4.69%-0.46 pp -310.40K (-10.43%) | Reduced | ↗▾ |
| 06 | PCVXVAXCYTE INC View history and evidence | $136.33M | 4.03% | 3.78M shares | 4.68% → 4.03%-0.65 pp +411.92K (+12.21%) | Added | ↗▾ |
| 07 | ABVXABIVAX SA-ADRSPONSORED ADS View history and evidence | $132.80M | 3.93% | 1.56M shares | Prior unavailable +1.56M | New | ↗▾ |
| 08 | GMABGENMAB A/S -SP ADRSPONSORED ADS View history and evidence | $117.06M | 3.46% | 3.82M shares | Prior unavailable +3.82M | New | ↗▾ |
| 09 | AGIOAGIOS PHARMACEUTICALS INC View history and evidence | $107.32M | 3.18% | 2.67M shares | 1.62% → 3.18%+1.56 pp +1.53M (+134.01%) | Added | ↗▾ |
| 10 | CRNXCRINETICS PHARMACEUTICALS IN View history and evidence | $106.24M | 3.14% | 2.55M shares | 2.88% → 3.14%+0.26 pp +207.22K (+8.84%) | Added | ↗▾ |
Options overlay 3
$136.47M notionalPut and Call positions are separate. Notional is based on underlying securities, not option premium, market value or net exposure. Quantities are underlying shares.
| Security | Put / Call | Underlying shares | Notional | Quantity change | |
|---|---|---|---|---|---|
XBISS SPDR S&P BIOTECH ETFS&P BIOTECH View history and evidence | Put | 1.00M | $100.20M | +1.00M | ▾ |
MRUSMERUS NV View history and evidence | Call | 300.00K | $28.25M | +300.00K | ▾ |
AGIOAGIOS PHARMACEUTICALS INC View history and evidence | Call | 200.00K | $8.03M | +200.00K | ▾ |
3 / 3 options · preview only
Exited positions 5
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| ONC BEONE MEDICINES LTD-ADR | Non-derivative | -347,787 | -$84.19M | SEC filing ↗ | SEC filing ↗ |
| MLTX MOONLAKE IMMUNOTHERAPEUTICS | Non-derivative | -878,323 | -$41.46M | SEC filing ↗ | SEC filing ↗ |
| YMAB Y-MABS THERAPEUTICS INC | Non-derivative | -4,236,346 | -$19.11M | SEC filing ↗ | SEC filing ↗ |
3 / 5 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 1855655 · Period 2025-09-30
Data loaded 2026-09-23 · First reported 2025-11-14
Amendments and versions
{
"amendments_merged": null,
"prior_versions": null,
"cover_table_value": 3516196926
}Research all 36 reported holdings.
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