Siren, L.L.C.
CIK 2005245 · Holdings on Dec 31, 2024 · First reported Feb 14, 2025
Top ten holdings
Q4 2024- SRRK17.66%
- ONC5.34%
- KYMR5.28%
- APLS3.97%
- CRNX3.64%
- ARGX3.13%
- BCAX2.52%
- ARWR2.41%
- NAMS2.38%
- SEPN2.23%
Share classes counted separately48.56%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- SRRKWeight increased · +13.15 pp4.51% → 17.66%Shares -2.01M (-17.85%)
- RNAWeight decreased · -1.86 pp3.31% → 1.45%Shares -313.44K (-21.76%)
- LXRXWeight decreased · -1.79 pp3.06% → 1.27%Shares 0 (0.00%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 29
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | SRRKSCHOLAR ROCK HOLDING CORP View history and evidence | $399.79M | 17.66% | 9.25M shares | 4.51% → 17.66%+13.15 pp -2.01M (-17.85%) | Reduced | ↗▾ |
| 02 | ONCBEONE MEDICINES LTD-ADRSPONSORED ADR View history and evidence | $120.75M | 5.34% | 653.72K shares | 6.33% → 5.34%-0.99 pp +90.41K (+16.05%) | Added | ↗▾ |
| 03 | KYMRKYMERA THERAPEUTICS INC View history and evidence | $119.47M | 5.28% | 2.97M shares | 7.03% → 5.28%-1.75 pp 0 (0.00%) | Unchanged | ↗▾ |
| 04 | APLSAPELLIS PHARMACEUTICALS INC View history and evidence | $89.87M | 3.97% | 2.82M shares | 3.13% → 3.97%+0.84 pp +649.03K (+29.95%) | Added | ↗▾ |
| 05 | CRNXCRINETICS PHARMACEUTICALS IN View history and evidence | $82.30M | 3.64% | 1.61M shares | 3.35% → 3.64%+0.29 pp +300.00K (+22.91%) | Added | ↗▾ |
| 06 | ARGXARGENX SE - ADRSPONSORED ADR View history and evidence | $70.75M | 3.13% | 115.05K shares | 3.90% → 3.13%-0.77 pp -28.60K (-19.91%) | Reduced | ↗▾ |
| 07 | BCAXBICARA THERAPEUTICS INC View history and evidence | $57.01M | 2.52% | 3.27M shares | 3.92% → 2.52%-1.40 pp +200.00K (+6.51%) | Added | ↗▾ |
| 08 | ARWRARROWHEAD PHARMACEUTICALS IN View history and evidence | $54.55M | 2.41% | 2.90M shares | 2.38% → 2.41%+0.03 pp +442.90K (+18.01%) | Added | ↗▾ |
| 09 | NAMSNEWAMSTERDAM PHARMA CO NVORDINARY SHARES View history and evidence | $53.86M | 2.38% | 2.10M shares | 0.76% → 2.38%+1.62 pp +1.18M (+127.65%) | Added | ↗▾ |
| 10 | SEPNSEPTERNA INC View history and evidence | $50.44M | 2.23% | 2.20M shares | Prior unavailable +2.20M | New | ↗▾ |
Options overlay 1
$187.25K notionalPut and Call positions are separate. Notional is based on underlying securities, not option premium, market value or net exposure. Quantities are underlying shares.
| Security | Put / Call | Underlying shares | Notional | Quantity change | |
|---|---|---|---|---|---|
GOSSGOSSAMER BIO INC View history and evidence | Call | 207.00K | $187.25K | 0 (0.00%) | ▾ |
1 / 1 options · preview only
Exited positions 16
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| LBPH LONGBOARD PHARMACEUTICALS IN | Non-derivative | -903,227 | -$30.10M | SEC filing ↗ | SEC filing ↗ |
| BHVN BIOHAVEN LTD | Non-derivative | -283,540 | -$14.17M | SEC filing ↗ | SEC filing ↗ |
| NGNE NEUROGENE INC | Non-derivative | -175,898 | -$7.38M | SEC filing ↗ | SEC filing ↗ |
3 / 16 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 2005245 · Period 2024-12-31
Data loaded 2026-09-23 · First reported 2025-02-14
Amendments and versions
{
"amendments_merged": null,
"prior_versions": null,
"cover_table_value": 2263488311
}Research all 118 reported holdings.
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