Company · Ownership research

Spyre Therapeutics, Inc. SYRE

CIK 0001636282

Form 4 transactions dated Sep 1, 2023 to Sep 23, 2026, as reported to the SEC.

Insider trading Initial holdings Institutional holders

This page lists 30 of 43 rows; the complete set is available through the API.

Insider filings on file run through 2026-09-03.

Some filings are submitted jointly by several insiders. The SEC form does not apportion the reported figures between them, so results include every joint filer.

Insider purchases & sales

Purchased: $0.00
Sold: $437.79M

Sep 1, 2023 – Sep 3, 2026
Available records · partial months are marked ·

202610 of 29 preview events

Date	Insider	Activity	Trade value (USD)	% of prior holding
2026-09-02	King-Jones Heidy See Remarks	Sale10b5-1 footnote	$36.00K 400 shares sold	12.33% sold Direct holding	▾
2026-09-02	Burrows Scott L Chief Financial Officer	Sale	$1.63M 18,232 shares sold	18.61% sold Direct holding	▾
2026-09-01	King-Jones Heidy See Remarks	Sale10b5-1 footnote	$2.44M 27,999 shares sold	90.78% sold Direct holding	▾
2026-09-01	Burrows Scott L Chief Financial Officer	Sale10b5-1 footnote	$654.79K 7,500 shares sold	7.11% sold Direct holding	▾
2026-09-01	Turtle Cameron Chief Executive Officer · Director	Sale10b5-1 footnote	$1.31M 15,000 shares sold	2.64% sold Direct holding	▾
2026-08-07	Albers Jeffrey W. Director	Sale10b5-1 footnote	$522.35K 5,000 shares sold	100.00% sold Direct holding	▾
2026-08-07	Albers Jeffrey W. Director	Sale10b5-1 footnote	$1.88M 18,000 shares sold	65.79% sold LLC holding	▾
2026-08-03	Burrows Scott L Chief Financial Officer	Sale10b5-1 footnote	$716.77K 7,500 shares sold	7.11% sold Direct holding	▾
2026-08-03	Turtle Cameron Chief Executive Officer · Director	Sale10b5-1 footnote	$1.43M 15,000 shares sold	2.57% sold Direct holding	▾
2026-07-01	Burrows Scott L Chief Financial Officer	Sale10b5-1 footnote	$658.04K 7,500 shares sold	7.11% sold Direct holding	▾

Showing 29 / 29 record groups in 2026. The complete set is available through the API.

Spyre Therapeutics, Inc. · SYRE

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The initial HTML of this page carries its exact data as script#research-data (JSON): values, units, scope, preview limits and SEC sources. Read it directly, no script or API key needed; script#research-access says what needs an account. For the year shown, this page lists 29 of 29 purchase / sale groups and 30 of 43 other groups; the totals and the monthly series cover the whole window.

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{"ticker":"SYRE","transaction_code":["P","S"],"transaction_form_type":"4","page_size":20}

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.

Non-cancelled, non-derivative purchase (P) and sale (S) rows dated inside the public window, as reported. Includes open-market and private transactions. Data after the latest filing is not asserted complete and is not zero-filled. A grouped event shares filing, transaction date, security, code, direction, ownership bucket and source. Derivative groups also match underlying security, exercise price, exercise/expiration dates and footnote references. Reported rows are retained; P/S price lots can be grouped. Post-transaction balances are never summed.