Company · Ownership research

Mineralys Therapeutics, Inc. MLYS

CIK 0001933414 · CUSIP 603170101

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 603170101 (MLYS), not CUSIP 603170901 (MLYS), CUSIP 603170951 (MLYS), CUSIP SBP9N0G08 (MLYS), and does not merge CUSIPs.

This page lists the top 20 of 224 rows by value; the complete set is available through the API.

Some filings reported values in thousands; those figures were scaled ×1,000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	Catalys Pacific, LLC CIK 2011385 · View history	$286.83M 7,903,838 shares	92.37%	-1.00M(-11.20%)Reduced	SEC filing ↗ Feb 10, 2026	▾
02	RA CAPITAL MANAGEMENT, L.P. CIK 1346824 · View history	$265.78M 7,323,750 shares	2.72%	0(0.00%)Unchanged	SEC filing ↗ Feb 17, 2026	▾
03	Samsara BioCapital, LLC CIK 1744967 · View history	$213.06M 5,871,018 shares	21.98%	-392.13K(-6.30%)Reduced	SEC filing ↗ Feb 17, 2026	▾
04	FMR LLC CIK 315066 · View history	$183.54M 5,057,509 shares	0.01%	+2.99M(+144.20%)Added	SEC filing ↗ Feb 17, 2026	▾
05	BlackRock, Inc. CIK 2012383 · View history	$157.05M 4,327,678 shares	0.00%	+656.06K(+17.90%)Added	SEC filing ↗ Feb 12, 2026	▾
06	VANGUARD GROUP INC CIK 102909 · View history	$121.68M 3,352,880 shares	0.00%	+333.88K(+11.10%)Added	SEC filing ↗ Jan 29, 2026	▾
07	STATE STREET CORP CIK 93751 · View history	$115.58M 3,184,999 shares	0.00%	+1.88M(+144.40%)Added	SEC filing ↗ Feb 13, 2026	▾
08	Caligan Partners LP CIK 1727492 · View history	$100.62M 2,772,654 shares	9.21%	0(0.00%)Unchanged	SEC filing ↗ Feb 17, 2026	▾
09	FRANKLIN RESOURCES INC CIK 38777 · View history	$64.91M 1,788,747 shares	0.02%	-21.02K(-1.20%)Reduced	SEC filing ↗ Feb 11, 2026	▾
10	Laurion Capital Management LP CIK 1390202 · Amended · View history	$62.18M 1,713,485 shares	4.24%	-6.96K(-0.40%)Reduced	SEC filing ↗ Feb 17, 2026	▾
11	Holocene Advisors, LP CIK 1700574 · View history	$58.14M 1,602,035 shares	0.12%	+396.66K(+32.90%)Added	SEC filing ↗ Feb 17, 2026	▾
12	ANDERA PARTNERS CIK 1757283 · View history	$57.77M 1,591,917 shares	32.71%	—	SEC filing ↗ Feb 17, 2026	▾
13	SR One Capital Management, LP CIK 1910264 · View history	$56.76M 1,563,966 shares	8.03%	-549.97K(-26.00%)Reduced	SEC filing ↗ Feb 12, 2026	▾
14	SUVRETTA CAPITAL MANAGEMENT, LLC CIK 1569064 · View history	$55.84M 1,538,662 shares	1.39%	-593.47K(-27.80%)Reduced	SEC filing ↗ Feb 17, 2026	▾
15	GOLDMAN SACHS GROUP INC CIK 886982 · Amended · View history	$52.65M 1,450,933 shares	0.01%	+739.27K(+103.90%)Added	SEC filing ↗ Mar 25, 2026	▾
16	Polar Capital Holdings Plc CIK 1837309 · View history	$50.85M 1,401,141 shares	0.23%	+342.37K(+32.30%)Added	SEC filing ↗ Feb 17, 2026	▾
17	PRICE T ROWE ASSOCIATES INC /MD/ CIK 80255 · View history	$48.09M 1,325,120 shares	0.01%	+1.30M(+6,097.10%)Added	SEC filing ↗ Feb 17, 2026	▾
18	SAMLYN CAPITAL, LLC CIK 1421097 · View history	$47.36M 1,304,932 shares	0.76%	+1.30MNew	SEC filing ↗ Feb 17, 2026	▾
19	JENNISON ASSOCIATES LLC CIK 53417 · View history	$45.68M 1,258,653 shares	0.03%	+882.31K(+234.40%)Added	SEC filing ↗ Jan 30, 2026	▾
20	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$45.64M 1,257,582 shares	0.00%	+134.17K(+11.90%)Added	SEC filing ↗ Feb 9, 2026	▾

Showing 20 / 224 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

224

Cancelled or null records excluded

Disclosed shares

88,386,859

Not deduplicated across managers

Disclosed value

$3.21B

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Mineralys Therapeutics, Inc. · Q4 2025

Explore all 224 reporting institutions.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.