Upstream Bio, Inc. UPB
CIK 0002022626 · CUSIP 91678A107
Quarter-end disclosures, not live holdings.
Top 20 institutions
Weight means this stock's share of the manager's own portfolio.
| # | Manager | Value | Manager weight | Change vs prior | Source | |
|---|---|---|---|---|---|---|
| 01 | FMR LLC CIK 315066 · View history | $117.98M 7,176,187 shares | 0.01% | +7.18MNew | SEC filing ↗ Feb 13, 2025 | ▾ |
| 02 | ORBIMED ADVISORS LLC CIK 1055951 · View history | $93.60M 5,693,589 shares | 1.95% | +5.69MNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 03 | Decheng Capital LLC CIK 2010850 · View history | $54.01M 3,285,293 shares | 11.58% | +3.29MNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 04 | TCG Crossover Management, LLC CIK 1839948 · View history | $44.86M 2,801,763 shares | 4.38% | +2.80MNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 05 | ENAVATE SCIENCES GP, LLC CIK 1953107 · View history | $40.44M 2,459,703 shares | 29.04% | — | SEC filing ↗ Feb 14, 2025 | ▾ |
| 06 | Bain Capital Life Sciences Investors, LLC CIK 1703031 · View history | $37.74M 2,295,322 shares | 4.44% | +2.30MNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 07 | Venrock Adviser, LLC CIK 1615982 · View history | $37.74M 2,295,319 shares | 2.59% | +2.30MNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 08 | SAMSARA BIOCAPITAL, LLC CIK 1744967 · View history | $36.45M 2,217,146 shares | 5.00% | +2.22MNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 09 | Omega Fund Management, LLC CIK 1637359 · Amended · View history | $33.48M 2,036,293 shares | 21.71% | +2.04MNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 10 | WELLINGTON MANAGEMENT GROUP LLP CIK 902219 · Amended · View history | $25.63M 1,583,154 shares | 0.00% | +1.58MNew | SEC filing ↗ Feb 12, 2025 | ▾ |
| 11 | BlackRock, Inc. CIK 2012383 · View history | $18.38M 1,117,800 shares | 0.00% | +1.12MNew | SEC filing ↗ Feb 7, 2025 | ▾ |
| 12 | ALLIANCEBERNSTEIN L.P. CIK 1109448 · View history | $18.27M 1,111,337 shares | 0.01% | +1.11MNew | SEC filing ↗ Feb 12, 2025 | ▾ |
| 13 | NORGES BANK CIK 1374170 · View history | $16.44M 1,000,000 shares | 0.00% | +1.00MNew | SEC filing ↗ Feb 12, 2025 | ▾ |
| 14 | Deep Track Capital, LP CIK 1856083 · View history | $16.44M 1,000,000 shares | 0.62% | +1.00MNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 15 | VANGUARD GROUP INC CIK 102909 · View history | $15.04M 915,021 shares | 0.00% | +915.02KNew | SEC filing ↗ Feb 11, 2025 | ▾ |
| 16 | Siren, L.L.C. CIK 2005245 · View history | $13.15M 800,000 shares | 0.58% | +800.00KNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 17 | Nantahala Capital Management, LLC CIK 1472322 · View history | $9.86M 600,000 shares | 0.69% | +600.00KNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 18 | Woodline Partners LP CIK 1784547 · View history | $8.66M 526,511 shares | 0.06% | +526.51KNew | SEC filing ↗ Feb 14, 2025 | ▾ |
| 19 | GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history | $5.97M 363,269 shares | 0.00% | +363.27KNew | SEC filing ↗ Feb 12, 2025 | ▾ |
| 20 | Balyasny Asset Management L.P. CIK 1218710 · View history | $4.95M 301,152 shares | 0.01% | +301.15KNew | SEC filing ↗ Feb 14, 2025 | ▾ |
Showing 20 / 71 institutions. The complete set is available through the API.
Coverage & totals by quarter
Reporting institutions by quarter
Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.
Explore all 71 reporting institutions.
This page includes 20 of 71 reporting institutions. Sign in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.
- Download CSV
- Earlier quarters
- Advanced screening & filtering
- API & AI access
+ New accounts get free API credits to explore data beyond ownership filings.
For AI agents & developers
The initial HTML of this page carries its exact data as script#research-data (JSON): values, units, scope, preview limits and SEC sources. Read it directly, no script or API key needed; script#research-access says what needs an account. This page lists 20 of 71 reporting institutions; totals use the complete disclosed data.
Without an account: the last 3 years, with the row caps stated on the page. A free account opens all history on file on these pages and the CSV of what a page shows. Rows beyond the caps and bulk retrieval go through the authenticated API / MCP.
MCP https://api.akkrudata.ai/mcp
get_institutional_security_holders
{"cusip":"91678A107","quarter":"2024Q4","type":"positions","page_size":100}Connect to MCP with OAuth and follow the returned pagination. Credits and usage limits depend on the account.
- MCP endpoint
- https://api.akkrudata.ai/mcp
- API / MCP documentation
- /documents
- llms.txt
- /llms.txt
Sources, coverage & how to read this data
Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.