GREAT POINT PARTNERS LLC
CIK 1281446 · Holdings on Jun 30, 2025 · First reported Aug 14, 2025
Top ten holdings
Q2 2025- IONS12.84%
- RZLT8.80%
- AMLX8.34%
- LEGN8.08%
- ABVX6.42%
- NGNE4.72%
- AKBA4.70%
- EOLS4.31%
- ACLX4.28%
- XENE4.07%
Share classes counted separately66.56%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- IONSWeight increased · +8.74 pp4.10% → 12.84%Shares +250.00K (+100.00%)
- RZLTWeight increased · +7.49 pp1.31% → 8.80%Shares +2.20M (+264.14%)
- LEGNWeight increased · +5.53 pp2.55% → 8.08%Shares +211.76K (+153.18%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 26
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | IONSIONIS PHARMACEUTICALS INC View history and evidence | $19.75M | 12.84% | 500.00K shares | 4.10% → 12.84%+8.74 pp +250.00K (+100.00%) | Added | ↗▾ |
| 02 | RZLTREZOLUTE INCCOM NEW View history and evidence | $13.53M | 8.80% | 3.03M shares | 1.31% → 8.80%+7.49 pp +2.20M (+264.14%) | Added | ↗▾ |
| 03 | AMLXAMYLYX PHARMACEUTICALS INC View history and evidence | $12.82M | 8.34% | 2.00M shares | 3.49% → 8.34%+4.85 pp +188.00K (+10.38%) | Added | ↗▾ |
| 04 | LEGNLEGEND BIOTECH CORP-ADRSPONSORED ADS View history and evidence | $12.42M | 8.08% | 350.00K shares | 2.55% → 8.08%+5.53 pp +211.76K (+153.18%) | Added | ↗▾ |
| 05 | ABVXABIVAX SA-ADRSPONSORED ADS View history and evidence | $9.88M | 6.42% | 1.29M shares | 5.57% → 6.42%+0.85 pp -346.49K (-21.15%) | Reduced | ↗▾ |
| 06 | NGNENEUROGENE INC View history and evidence | $7.26M | 4.72% | 485.86K shares | 3.00% → 4.72%+1.72 pp +14.89K (+3.16%) | Added | ↗▾ |
| 07 | AKBAAKEBIA THERAPEUTICS INC View history and evidence | $7.23M | 4.70% | 1.99M shares | 5.19% → 4.70%-0.49 pp -2.99M (-60.07%) | Reduced | ↗▾ |
| 08 | EOLSEVOLUS INC View history and evidence | $6.63M | 4.31% | 720.12K shares | 6.18% → 4.31%-1.87 pp -224.63K (-23.78%) | Reduced | ↗▾ |
| 09 | ACLXARCELLX INCCOMMON STOCK View history and evidence | $6.58M | 4.28% | 100.00K shares | 1.60% → 4.28%+2.68 pp +55.00K (+122.22%) | Added | ↗▾ |
| 10 | XENEXENON PHARMACEUTICALS INC View history and evidence | $6.26M | 4.07% | 200.00K shares | 4.47% → 4.07%-0.40 pp -45.27K (-18.46%) | Reduced | ↗▾ |
Options overlay 0
No options reported this quarter.
Exited positions 11
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| VRDN VIRIDIAN THERAPEUTICS INC | Non-derivative | -750,000 | -$10.11M | SEC filing ↗ | SEC filing ↗ |
| MRUS MERUS NV | Non-derivative | -237,156 | -$9.98M | SEC filing ↗ | SEC filing ↗ |
| ASND ASCENDIS PHARMA A/S | Non-derivative | -50,000 | -$7.79M | SEC filing ↗ | SEC filing ↗ |
3 / 11 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 1281446 · Period Jun 30, 2025
Data loaded Sep 23, 2026 · First reported Aug 14, 2025
Amendments and versions
{
"amendments_merged": null,
"prior_versions": null,
"cover_table_value": 153801796
}Take these holdings further.
This page includes 26 of 26 reported holdings. Log in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.
- Download CSV
- Earlier quarters
- Advanced screening & filtering
- API & AI access
＋ New accounts get free API credits to explore data beyond ownership filings.
For AI agents & developers
The initial HTML of this page carries its exact data as script#portfolio-data (JSON): values, units, scope, preview limits and SEC sources. Read it directly, no script or API key needed; script#research-access says what needs an account. This page lists 26 of 26 current positions (options included); totals and weights use the complete filing.
Without an account: the last 3 years, with the row caps stated on the page. A free account opens all history on file on these pages and the CSV of what a page shows. Rows beyond the caps and bulk retrieval go through the authenticated API / MCP / CLI.
MCP https://api.akkrudata.ai/mcp
akkru_institutional_holdings
{"action":"portfolio","cik":"1281446","quarter":"2025Q2","page_size":100}
akkru_institutional_holdings
{"action":"history","cik":"1281446","page_size":100}Connect to MCP with OAuth and follow the returned pagination. Credits and usage limits depend on the account.
- MCP endpoint
- https://api.akkrudata.ai/mcp
- API / MCP / CLI documentation
- /documents
- llms.txt
- /llms.txt
Sources, coverage & how to read this data
Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.