GREAT POINT PARTNERS LLC
CIK 1281446 · Holdings on Sep 30, 2025 · First reported Nov 14, 2025
Top ten holdings
Q3 2025- AMLX9.65%
- RZLT9.62%
- NKTR7.13%
- ZURA6.90%
- SLNO6.35%
- ASND6.23%
- ABVX5.32%
- APGE5.04%
- DNTH4.37%
- CYTK3.44%
Share classes counted separately64.05%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- IONSWeight decreased · -10.65 pp12.84% → 2.19%Shares -420.00K (-84.00%)
- LEGNWeight decreased · -6.54 pp8.08% → 1.54%Shares -236.54K (-67.58%)
- ZURAWeight increased · +4.74 pp2.16% → 6.90%Shares +645.74K (+20.37%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 28
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | AMLXAMYLYX PHARMACEUTICALS INC View history and evidence | $23.10M | 9.65% | 1.70M shares | 8.34% → 9.65%+1.31 pp -300.00K (-15.00%) | Reduced | ↗▾ |
| 02 | RZLTREZOLUTE INC View history and evidence | $23.05M | 9.62% | 2.45M shares | 8.80% → 9.62%+0.82 pp -581.65K (-19.17%) | Reduced | ↗▾ |
| 03 | NKTRNEKTAR THERAPEUTICS View history and evidence | $17.07M | 7.13% | 300.00K shares | Prior unavailable +300.00K | New | ↗▾ |
| 04 | ZURAZURA BIO LTD View history and evidence | $16.52M | 6.90% | 3.82M shares | 2.16% → 6.90%+4.74 pp +645.74K (+20.37%) | Added | ↗▾ |
| 05 | SLNOSOLENO THERAPEUTICS INC View history and evidence | $15.21M | 6.35% | 225.00K shares | Prior unavailable +225.00K | New | ↗▾ |
| 06 | ASNDASCENDIS PHARMA A/S View history and evidence | $14.91M | 6.23% | 75.00K shares | Prior unavailable +75.00K | New | ↗▾ |
| 07 | ABVXABIVAX SA-ADR View history and evidence | $12.73M | 5.32% | 150.00K shares | 6.42% → 5.32%-1.10 pp -1.14M (-88.39%) | Reduced | ↗▾ |
| 08 | APGEAPOGEE THERAPEUTICS INC View history and evidence | $12.08M | 5.04% | 304.00K shares | Prior unavailable +304.00K | New | ↗▾ |
| 09 | DNTHDIANTHUS THERAPEUTICS INC View history and evidence | $10.46M | 4.37% | 265.80K shares | Prior unavailable +265.80K | New | ↗▾ |
| 10 | CYTKCYTOKINETICS INC View history and evidence | $8.24M | 3.44% | 150.00K shares | 3.22% → 3.44%+0.22 pp 0 (0.00%) | Unchanged | ↗▾ |
Options overlay 2
$2.97M notionalPut and Call positions are separate. Notional is based on underlying securities, not option premium, market value or net exposure. Quantities are underlying shares.
| Security | Put / Call | Underlying shares | Notional | Quantity change | |
|---|---|---|---|---|---|
HRMYHARMONY BIOSCIENCES HOLDINGS View history and evidence | Call | 85.00K | $2.34M | +85.00K | ▾ |
CAPRCAPRICOR THERAPEUTICS INC View history and evidence | Put | 87.70K | $632.32K | +87.70K | ▾ |
2 / 2 options · preview only
Exited positions 8
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| AKBA AKEBIA THERAPEUTICS INC | Non-derivative | -1,985,915 | -$7.23M | SEC filing ↗ | SEC filing ↗ |
| EOLS EVOLUS INC | Non-derivative | -720,118 | -$6.63M | SEC filing ↗ | SEC filing ↗ |
| ACLX ARCELLX INC | Non-derivative | -100,000 | -$6.58M | SEC filing ↗ | SEC filing ↗ |
3 / 8 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 1281446 · Period 2025-09-30
Data loaded 2026-09-23 · First reported 2025-11-14
Amendments and versions
{
"amendments_merged": null,
"prior_versions": null,
"cover_table_value": 242495757
}Take these holdings further.
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