Company · Ownership research

IONIS PHARMACEUTICALS INC IONS

CIK 0000874015 · CUSIP 462222100

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 462222100 (IONS), not CUSIP 462222900 (IONS), CUSIP 462222950 (IONS), and does not merge CUSIPs.

This page lists the top 20 of 358 rows by value; the complete set is available through the API.

Some filings reported values in thousands; those figures were scaled ×1,000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	FMR LLC CIK 315066 · View history	$793.22M 22,689,491 shares	0.05%	+209.96K(+0.90%)Added	SEC filing ↗ Feb 13, 2025	▾
02	VANGUARD GROUP INC CIK 102909 · View history	$575.88M 16,472,539 shares	0.01%	+1.42M(+9.40%)Added	SEC filing ↗ Feb 11, 2025	▾
03	T. Rowe Price Investment Management, Inc. CIK 1897612 · View history	$495.36M 14,169,199 shares	0.31%	+1.08K(0.00%)Added	SEC filing ↗ Feb 14, 2025	▾
04	BlackRock, Inc. CIK 2012383 · View history	$407.83M 11,665,548 shares	0.01%	+852.52K(+7.90%)Added	SEC filing ↗ Feb 7, 2025	▾
05	Capital World Investors CIK 1422849 · View history	$400.83M 11,465,413 shares	0.06%	+3.64M(+46.50%)Added	SEC filing ↗ Feb 13, 2025	▾
06	WELLINGTON MANAGEMENT GROUP LLP CIK 902219 · Amended · View history	$303.18M 8,672,148 shares	0.06%	-63.64K(-0.70%)Reduced	SEC filing ↗ Feb 12, 2025	▾
07	Bellevue Group AG CIK 1674546 · View history	$275.09M 7,868,700 shares	5.30%	-5.70K(-0.10%)Reduced	SEC filing ↗ Feb 14, 2025	▾
08	STATE STREET CORP CIK 93751 · View history	$189.71M 5,426,413 shares	0.01%	+576.28K(+11.90%)Added	SEC filing ↗ Feb 14, 2025	▾
09	PRICE T ROWE ASSOCIATES INC /MD/ CIK 80255 · View history	$133.79M 3,826,939 shares	0.02%	-383.23K(-9.10%)Reduced	SEC filing ↗ Feb 14, 2025	▾
10	Tweedy, Browne Co LLC CIK 732905 · View history	$113.58M 3,248,863 shares	7.66%	-205.81K(-6.00%)Reduced	SEC filing ↗ Feb 12, 2025	▾
11	ORBIMED ADVISORS LLC CIK 1055951 · View history	$98.49M 2,817,347 shares	2.05%	+492.90K(+21.20%)Added	SEC filing ↗ Feb 14, 2025	▾
12	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$93.98M 2,687,248 shares	0.01%	+18.89K(+0.70%)Added	SEC filing ↗ Feb 12, 2025	▾
13	CITADEL ADVISORS LLC CIK 1423053 · View history	$75.72M 2,165,916 shares	0.07%	+1.76M(+439.90%)Added	SEC filing ↗ Feb 14, 2025	▾
14	Deep Track Capital, LP CIK 1856083 · View history	$67.61M 1,933,928 shares	2.53%	-266.07K(-12.10%)Reduced	SEC filing ↗ Feb 14, 2025	▾
15	UBS Group AG CIK 1610520 · View history	$67.04M 1,917,608 shares	0.02%	+1.75M(+1,042.20%)Added	SEC filing ↗ Feb 14, 2025	▾
16	MACQUARIE GROUP LTD CIK 1418333 · View history	$61.87M 1,769,743 shares	0.07%	-100.06K(-5.40%)Reduced	SEC filing ↗ Feb 14, 2025	▾
17	NORGES BANK CIK 1374170 · View history	$59.95M 1,714,762 shares	0.01%	-312.40K(-15.40%)Reduced	SEC filing ↗ Feb 12, 2025	▾
18	Clearbridge Investments, LLC CIK 1348883 · View history	$56.57M 1,618,220 shares	0.05%	-84.17K(-4.90%)Reduced	SEC filing ↗ Feb 12, 2025	▾
19	CHARLES SCHWAB INVESTMENT MANAGEMENT INC CIK 884546 · View history	$51.79M 1,481,440 shares	0.01%	+38.42K(+2.70%)Added	SEC filing ↗ Feb 6, 2025	▾
20	TWO SIGMA ADVISERS, LP CIK 1478735 · View history	$47.17M 1,349,211 shares	0.11%	+16.80K(+1.30%)Added	SEC filing ↗ Feb 14, 2025	▾

Showing 20 / 358 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

358

Cancelled or null records excluded

Disclosed shares

160,956,382

Not deduplicated across managers

Disclosed value

$5.61B

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

IONIS PHARMACEUTICALS INC · Q4 2024

Explore all 358 reporting institutions.

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{"action":"holders","cusip":"462222100","quarter":"2024Q4","type":"positions","page_size":100}

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.