Company · Ownership research

IONIS PHARMACEUTICALS INC IONS

CIK 0000874015 · CUSIP 462222100

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 462222100 (IONS), not CUSIP 462222900 (IONS), CUSIP 462222950 (IONS), and does not merge CUSIPs.

This page lists the top 20 of 498 rows by value; the complete set is available through the API.

Some filings reported values in thousands; those figures were scaled ×1,000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	FMR LLC CIK 315066 · View history	$1.84B 24,556,637 shares	0.10%	+484.54K(+2.00%)Added	SEC filing ↗ May 15, 2026	▾
02	Capital World Investors CIK 1422849 · View history	$1.59B 21,186,369 shares	0.22%	+3.23M(+18.00%)Added	SEC filing ↗ May 13, 2026	▾
03	BlackRock, Inc. CIK 2012383 · View history	$784.13M 10,442,476 shares	0.01%	-205.39K(-1.90%)Reduced	SEC filing ↗ May 13, 2026	▾
04	VANGUARD PORTFOLIO MANAGEMENT LLC CIK 2100121 · Amended · View history	$586.37M 7,808,902 shares	0.03%	—	SEC filing ↗ May 8, 2026	▾
05	VANGUARD CAPITAL MANAGEMENT LLC CIK 2100119 · Amended · View history	$534.52M 7,118,330 shares	0.01%	—	SEC filing ↗ May 15, 2026	▾
06	WELLINGTON MANAGEMENT GROUP LLP CIK 902219 · View history	$479.96M 6,391,816 shares	0.09%	+131.49K(+2.10%)Added	SEC filing ↗ May 15, 2026	▾
07	T. Rowe Price Investment Management, Inc. CIK 1897612 · View history	$462.48M 6,159,027 shares	0.32%	-2.95M(-32.40%)Reduced	SEC filing ↗ May 15, 2026	▾
08	TWO SIGMA INVESTMENTS, LP CIK 1179392 · View history	$439.85M 5,857,629 shares	0.37%	+3.20M(+120.30%)Added	SEC filing ↗ May 15, 2026	▾
09	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$305.20M 3,984,332 shares	0.02%	+835.48K(+26.50%)Added	SEC filing ↗ May 15, 2026	▾
10	STATE STREET CORP CIK 93751 · View history	$300.03M 3,995,564 shares	0.01%	+20.70K(+0.50%)Added	SEC filing ↗ May 15, 2026	▾
11	ROYAL BANK OF CANADA CIK 1000275 · View history	$285.48M 3,801,815 shares	0.05%	+2.68M(+239.80%)Added	SEC filing ↗ May 15, 2026	▾
12	PRICE T ROWE ASSOCIATES INC /MD/ CIK 80255 · View history	$227.17M 3,025,251 shares	0.03%	+37.41K(+1.30%)Added	SEC filing ↗ May 15, 2026	▾
13	JPMORGAN CHASE & CO CIK 19617 · Amended · View history	$171.41M 2,363,567 shares	0.01%	+58.77K(+2.60%)Added	SEC filing ↗ May 13, 2026	▾
14	Tweedy, Browne Co LLC CIK 732905 · View history	$170.88M 2,275,625 shares	13.57%	-189.31K(-7.70%)Reduced	SEC filing ↗ May 6, 2026	▾
15	Artisan Partners Limited Partnership CIK 1466153 · View history	$154.56M 2,058,308 shares	0.25%	+876.89K(+74.20%)Added	SEC filing ↗ May 13, 2026	▾
16	BAKER BROS. ADVISORS LP CIK 1263508 · View history	$153.76M 2,047,727 shares	0.88%	+255.89K(+14.30%)Added	SEC filing ↗ May 15, 2026	▾
17	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) CIK 1009258 · View history	$148.65M 1,979,669 shares	1.75%	0(0.00%)Unchanged	SEC filing ↗ May 15, 2026	▾
18	Deep Track Capital, LP CIK 1856083 · View history	$146.43M 1,950,000 shares	3.02%	+250.00K(+14.70%)Added	SEC filing ↗ May 15, 2026	▾
19	Bellevue Group AG CIK 1674546 · View history	$136.56M 1,818,665 shares	3.25%	-2.98M(-62.10%)Reduced	SEC filing ↗ May 15, 2026	▾
20	GOLDMAN SACHS GROUP INC CIK 886982 · View history	$127.64M 1,699,847 shares	0.02%	+843.88K(+98.60%)Added	SEC filing ↗ May 15, 2026	▾

Showing 20 / 498 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

498

Cancelled or null records excluded

Disclosed shares

172,601,809

Not deduplicated across managers

Disclosed value

$12.97B

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

IONIS PHARMACEUTICALS INC · Q1 2026

Explore all 498 reporting institutions.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.