Company · Ownership research

LEXICON PHARMACEUTICALS, INC. LXRX

CIK 0001062822 · CUSIP 528872302

Insider tradingInitial holdingsInstitutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 528872302 (LXRX), not CUSIP 528872902 (LXRX), CUSIP 528872952 (LXRX), and does not merge CUSIPs.

This page lists the top 20 of 88 rows by value; the complete set is available through the API.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	Artal Group S.A. CIK 1053906 · View history	$329.29M 175,156,062 shares	47.96%	0(0.00%)Unchanged	SEC filing ↗ Nov 12, 2026	▾
02	FMR LLC CIK 315066 · View history	$125.14M 66,743,390 shares	0.01%	+14.96M(+28.90%)Added	SEC filing ↗ Nov 10, 2026	▾
03	Siren, L.L.C. CIK 2005245 · View history	$83.29M 44,303,518 shares	1.97%	0(0.00%)Unchanged	SEC filing ↗ Nov 12, 2026	▾
04	STATE STREET CORP CIK 93751 · View history	$14.00M 7,467,459 shares	0.00%	+2.55M(+51.80%)Added	SEC filing ↗ Nov 12, 2026	▾
05	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$11.05M 5,891,974 shares	0.00%	-352.40K(-5.60%)Reduced	SEC filing ↗ Nov 6, 2026	▾
06	UBS Group AG CIK 1610520 · View history	$3.42M 1,826,437 shares	0.00%	+1.14M(+166.70%)Added	SEC filing ↗ Nov 10, 2026	▾
07	Nuveen, LLC CIK 1871926 · View history	$1.04M 555,311 shares	0.00%	-31.35K(-5.30%)Reduced	SEC filing ↗ Nov 10, 2026	▾
08	Bank of New York Mellon Corp CIK 1390777 · View history	$1.00M 535,048 shares	0.00%	-33.66K(-5.90%)Reduced	SEC filing ↗ Nov 5, 2026	▾
09	Squarepoint Ops LLC CIK 1642575 · View history	$939.72K 501,186 shares	0.00%	+489.44K(+4,168.70%)Added	SEC filing ↗ Nov 9, 2026	▾
10	Compagnie Lombard Odier SCmA CIK 1615423 · View history	$900.00K 480,000 shares	0.01%	0(0.00%)Unchanged	SEC filing ↗ Nov 4, 2026	▾
11	Invesco Ltd. CIK 914208 · View history	$811.15K 432,615 shares	0.00%	-75.46K(-14.90%)Reduced	SEC filing ↗ Nov 12, 2026	▾
12	Swiss National Bank CIK 1582202 · View history	$799.88K 426,600 shares	0.00%	+426.60KNew	SEC filing ↗ Nov 12, 2026	▾
13	PROFUND ADVISORS LLC CIK 1129919 · View history	$638.40K 340,479 shares	0.02%	+291.89K(+600.80%)Added	SEC filing ↗ Oct 29, 2026	▾
14	FRANKLIN RESOURCES INC CIK 38777 · View history	$468.26K 316,390 shares	0.00%	+316.39KNew	SEC filing ↗ Nov 12, 2026	▾
15	RHUMBLINE ADVISERS CIK 1115418 · View history	$450.74K 240,396 shares	0.00%	-16.49K(-6.40%)Reduced	SEC filing ↗ Nov 10, 2026	▾
16	JANE STREET GROUP, LLC CIK 1595888 · View history	$430.47K 229,585 shares	0.00%	+229.59KNew	SEC filing ↗ Nov 12, 2026	▾
17	Scheeler Financial LLC CIK 2152854 · View history	$407.72K 217,452 shares	0.31%	—	SEC filing ↗ Oct 13, 2026	▾
18	DEUTSCHE BANK AG\ CIK 948046 · View history	$375.36K 199,661 shares	0.00%	-47.87K(-19.30%)Reduced	SEC filing ↗ Nov 6, 2026	▾
19	Johnson Dunn Capital Advisors Inc CIK 2164865 · View history	$375.00K 200,000 shares	0.27%	—	SEC filing ↗ Nov 12, 2026	▾
20	Virtus Investment Advisers, LLC CIK 19481 · View history	$309.90K 165,278 shares	0.07%	-5.14K(-3.00%)Reduced	SEC filing ↗ Nov 12, 2026	▾

Showing 20 / 88 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

Cancelled or null records excluded

Disclosed shares

308,244,570

Not deduplicated across managers

Disclosed value

$578.91M

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

LEXICON PHARMACEUTICALS, INC. · Q3 2026

Explore all 88 reporting institutions.

This page includes 20 of 88 reporting institutions. Log in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.