Company · Ownership research

LEXICON PHARMACEUTICALS, INC. LXRX

CIK 0001062822 · CUSIP 528872302

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 528872302 (LXRX), not CUSIP 528872902 (LXRX), CUSIP 528872952 (LXRX), and does not merge CUSIPs.

This page lists the top 20 of 126 rows by value; the complete set is available through the API.

Some filings reported values in thousands; those figures were scaled ×1,000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	Artal Group S.A. CIK 1053906 · View history	$156.61M 136,180,481 shares	21.91%	0(0.00%)Unchanged	SEC filing ↗ Feb 12, 2026	▾
02	Siren, L.L.C. CIK 2005245 · View history	$44.76M 38,918,903 shares	1.34%	0(0.00%)Unchanged	SEC filing ↗ Feb 13, 2026	▾
03	FMR LLC CIK 315066 · View history	$43.51M 37,834,207 shares	0.00%	-845.54K(-2.20%)Reduced	SEC filing ↗ Feb 17, 2026	▾
04	VANGUARD GROUP INC CIK 102909 · View history	$11.05M 9,606,549 shares	0.00%	+84.67K(+0.90%)Added	SEC filing ↗ Jan 29, 2026	▾
05	MILLENNIUM MANAGEMENT LLC CIK 1273087 · View history	$5.54M 4,821,733 shares	0.00%	+991.07K(+25.90%)Added	SEC filing ↗ Feb 17, 2026	▾
06	BlackRock, Inc. CIK 2012383 · View history	$3.67M 3,192,448 shares	0.00%	-202.52K(-6.00%)Reduced	SEC filing ↗ Feb 12, 2026	▾
07	UBS Group AG CIK 1610520 · View history	$3.46M 3,007,237 shares	0.00%	+2.65M(+752.10%)Added	SEC filing ↗ Jan 29, 2026	▾
08	Sessa Capital IM, L.P. CIK 1595849 · View history	$3.45M 3,000,000 shares	0.07%	0(0.00%)Unchanged	SEC filing ↗ Feb 17, 2026	▾
09	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$2.88M 2,500,022 shares	0.00%	+102.10K(+4.30%)Added	SEC filing ↗ Feb 9, 2026	▾
10	CIBC Private Wealth Group LLC CIK 1298088 · View history	$2.24M 1,950,000 shares	0.00%	-450.26K(-18.80%)Reduced	SEC filing ↗ Feb 12, 2026	▾
11	JANE STREET GROUP, LLC CIK 1595888 · View history	$1.98M 1,724,304 shares	0.00%	+1.27M(+277.70%)Added	SEC filing ↗ Feb 12, 2026	▾
12	CITADEL ADVISORS LLC CIK 1423053 · View history	$1.97M 1,710,975 shares	0.00%	-923.05K(-35.00%)Reduced	SEC filing ↗ Feb 17, 2026	▾
13	MARSHALL WACE, LLP CIK 1318757 · View history	$1.45M 1,262,367 shares	0.00%	+1.26MNew	SEC filing ↗ Feb 13, 2026	▾
14	SUSQUEHANNA INTERNATIONAL GROUP, LLP CIK 1446194 · View history	$1.39M 1,207,242 shares	0.00%	+245.18K(+25.50%)Added	SEC filing ↗ Feb 17, 2026	▾
15	CHARLES SCHWAB INVESTMENT MANAGEMENT INC CIK 884546 · View history	$1.21M 1,055,123 shares	0.00%	-89.51K(-7.80%)Reduced	SEC filing ↗ Feb 13, 2026	▾
16	GSA CAPITAL PARTNERS LLP CIK 1362033 · View history	$1.15M 996,235 shares	0.10%	-206.67K(-17.20%)Reduced	SEC filing ↗ Feb 6, 2026	▾
17	GOLDMAN SACHS GROUP INC CIK 886982 · Amended · View history	$1.06M 921,204 shares	0.00%	+861.86K(+1,452.20%)Added	SEC filing ↗ Mar 25, 2026	▾
18	Hennion & Walsh Asset Management, Inc. CIK 1861642 · View history	$1.04M 901,222 shares	0.04%	+122.01K(+15.70%)Added	SEC filing ↗ Jan 14, 2026	▾
19	STATE STREET CORP CIK 93751 · View history	$1.02M 884,738 shares	0.00%	+4.62K(+0.50%)Added	SEC filing ↗ Feb 13, 2026	▾
20	Ishara Investments LP CIK 2111609 · View history	$1.01M 880,000 shares	1.18%	—	SEC filing ↗ Feb 17, 2026	▾

Showing 20 / 126 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

126

Cancelled or null records excluded

Disclosed shares

260,427,476

Not deduplicated across managers

Disclosed value

$299.49M

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

LEXICON PHARMACEUTICALS, INC. · Q4 2025

Explore all 126 reporting institutions.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.