Company · Ownership research

Praxis Precision Medicines, Inc. PRAX

CIK 0001689548 · CUSIP 74006W207

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 74006W207 (PRAX), not CUSIP 74006W907 (PRAX), CUSIP 74006W957 (PRAX), CUSIP 74006W108 (PRAX), CUSIP SBNGFSD88 (PRAX), and does not merge CUSIPs.

This page lists the top 20 of 251 rows by value; the complete set is available through the API.

Some filings reported values in thousands; those figures were scaled ×1,000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	JANUS HENDERSON GROUP PLC CIK 1274173 · View history	$954.83M 3,240,086 shares	0.43%	+476.23K(+17.20%)Added	SEC filing ↗ Feb 17, 2026	▾
02	BlackRock, Inc. CIK 2012383 · View history	$612.62M 2,078,500 shares	0.01%	+277.42K(+15.40%)Added	SEC filing ↗ Feb 12, 2026	▾
03	PERCEPTIVE ADVISORS LLC CIK 1224962 · View history	$588.30M 1,995,986 shares	10.78%	+431.43K(+27.60%)Added	SEC filing ↗ Feb 17, 2026	▾
04	VANGUARD GROUP INC CIK 102909 · View history	$430.60M 1,460,933 shares	0.01%	+193.65K(+15.30%)Added	SEC filing ↗ Jan 29, 2026	▾
05	FMR LLC CIK 315066 · View history	$400.46M 1,358,675 shares	0.02%	+1.32M(+3,044.30%)Added	SEC filing ↗ Feb 17, 2026	▾
06	Orbis Allan Gray Ltd CIK 1663865 · View history	$369.95M 1,255,162 shares	1.55%	+1.26MNew	SEC filing ↗ Feb 17, 2026	▾
07	BAKER BROS. ADVISORS LP CIK 1263508 · View history	$332.02M 1,126,488 shares	1.94%	+437.00K(+63.40%)Added	SEC filing ↗ Feb 17, 2026	▾
08	ADAGE CAPITAL PARTNERS GP, L.L.C. CIK 1165408 · View history	$284.52M 965,313 shares	0.43%	-1.41M(-59.30%)Reduced	SEC filing ↗ Feb 17, 2026	▾
09	Cormorant Asset Management, LP CIK 1583977 · View history	$280.00M 950,000 shares	15.87%	-50.00K(-5.00%)Reduced	SEC filing ↗ Feb 17, 2026	▾
10	Driehaus Capital Management LLC CIK 938206 · View history	$275.01M 933,061 shares	1.87%	+432.51K(+86.40%)Added	SEC filing ↗ Feb 17, 2026	▾
11	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) CIK 1009258 · View history	$266.25M 903,351 shares	3.41%	+62.50K(+7.40%)Added	SEC filing ↗ Feb 17, 2026	▾
12	MORGAN STANLEY CIK 895421 · Amended · View history	$262.29M 889,889 shares	0.02%	+246.39K(+38.30%)Added	SEC filing ↗ May 27, 2026	▾
13	STATE STREET CORP CIK 93751 · View history	$260.02M 882,215 shares	0.01%	-24.89K(-2.70%)Reduced	SEC filing ↗ Feb 13, 2026	▾
14	PRICE T ROWE ASSOCIATES INC /MD/ CIK 80255 · View history	$231.66M 785,987 shares	0.02%	-217.50K(-21.70%)Reduced	SEC filing ↗ Feb 17, 2026	▾
15	GOLDMAN SACHS GROUP INC CIK 886982 · Amended · View history	$211.09M 716,184 shares	0.03%	+123.16K(+20.80%)Added	SEC filing ↗ Mar 25, 2026	▾
16	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$165.78M 562,379 shares	0.01%	+105.35K(+23.10%)Added	SEC filing ↗ Feb 9, 2026	▾
17	BARCLAYS PLC CIK 312069 · View history	$156.43M 530,751 shares	0.06%	+454.11K(+592.60%)Added	SEC filing ↗ Feb 13, 2026	▾
18	BANK OF AMERICA CORP /DE/ CIK 70858 · View history	$154.08M 522,763 shares	0.01%	+39.90K(+8.30%)Added	SEC filing ↗ Feb 17, 2026	▾
19	Point72 Asset Management, L.P. CIK 1603466 · View history	$145.11M 492,346 shares	0.23%	-1.00M(-67.10%)Reduced	SEC filing ↗ Feb 17, 2026	▾
20	Assenagon Asset Management S.A. CIK 1546007 · View history	$120.49M 408,787 shares	0.18%	-992(-0.20%)Reduced	SEC filing ↗ Jan 9, 2026	▾

Showing 20 / 251 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

251

Cancelled or null records excluded

Disclosed shares

29,469,062

Not deduplicated across managers

Disclosed value

$8.69B

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Praxis Precision Medicines, Inc. · Q4 2025

Explore all 251 reporting institutions.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.