Company · Ownership research

Praxis Precision Medicines, Inc. PRAX

CIK 0001689548 · CUSIP 74006W207

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 74006W207 (PRAX), not CUSIP 74006W907 (PRAX), CUSIP 74006W957 (PRAX), CUSIP 74006W108 (PRAX), CUSIP SBNGFSD88 (PRAX), and does not merge CUSIPs.

This page lists the top 20 of 293 rows by value; the complete set is available through the API.

Some filings reported values in thousands; those figures were scaled ×1,000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	JANUS HENDERSON GROUP PLC CIK 1274173 · Amended · View history	$1.11B 3,458,863 shares	0.53%	+218.78K(+6.80%)Added	SEC filing ↗ May 18, 2026	▾
02	Orbis Allan Gray Ltd CIK 1663865 · View history	$796.61M 2,472,480 shares	3.36%	+1.22M(+97.00%)Added	SEC filing ↗ May 15, 2026	▾
03	BlackRock, Inc. CIK 2012383 · View history	$749.07M 2,324,929 shares	0.01%	+246.43K(+11.90%)Added	SEC filing ↗ May 13, 2026	▾
04	FMR LLC CIK 315066 · View history	$696.23M 2,160,943 shares	0.04%	+802.27K(+59.00%)Added	SEC filing ↗ May 15, 2026	▾
05	PERCEPTIVE ADVISORS LLC CIK 1224962 · Amended · View history	$655.97M 2,035,986 shares	12.96%	+40.00K(+2.00%)Added	SEC filing ↗ May 29, 2026	▾
06	BAKER BROS. ADVISORS LP CIK 1263508 · View history	$564.86M 1,753,198 shares	3.24%	+626.71K(+55.60%)Added	SEC filing ↗ May 15, 2026	▾
07	VANGUARD CAPITAL MANAGEMENT LLC CIK 2100119 · Amended · View history	$393.70M 1,221,944 shares	0.01%	—	SEC filing ↗ May 15, 2026	▾
08	DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) CIK 1009258 · View history	$310.38M 963,351 shares	3.66%	+60.00K(+6.60%)Added	SEC filing ↗ May 15, 2026	▾
09	Driehaus Capital Management LLC CIK 938206 · View history	$305.83M 949,225 shares	2.25%	+16.16K(+1.70%)Added	SEC filing ↗ May 15, 2026	▾
10	Cormorant Asset Management, LP CIK 1583977 · View history	$285.30M 885,500 shares	14.38%	-64.50K(-6.80%)Reduced	SEC filing ↗ May 15, 2026	▾
11	STATE STREET CORP CIK 93751 · View history	$284.89M 884,238 shares	0.01%	+2.02K(+0.20%)Added	SEC filing ↗ May 15, 2026	▾
12	MORGAN STANLEY CIK 895421 · View history	$268.54M 833,491 shares	0.02%	-56.40K(-6.30%)Reduced	SEC filing ↗ May 15, 2026	▾
13	ADAGE CAPITAL PARTNERS GP, L.L.C. CIK 1165408 · View history	$262.82M 815,739 shares	0.41%	-149.57K(-15.50%)Reduced	SEC filing ↗ May 15, 2026	▾
14	VANGUARD PORTFOLIO MANAGEMENT LLC CIK 2100121 · Amended · View history	$243.82M 756,748 shares	0.01%	—	SEC filing ↗ May 8, 2026	▾
15	GOLDMAN SACHS GROUP INC CIK 886982 · View history	$228.99M 710,734 shares	0.03%	-5.45K(-0.80%)Reduced	SEC filing ↗ May 15, 2026	▾
16	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$209.75M 650,904 shares	0.01%	+88.53K(+15.70%)Added	SEC filing ↗ May 15, 2026	▾
17	PRICE T ROWE ASSOCIATES INC /MD/ CIK 80255 · View history	$203.25M 630,852 shares	0.02%	-155.13K(-19.70%)Reduced	SEC filing ↗ May 15, 2026	▾
18	BANK OF AMERICA CORP /DE/ CIK 70858 · View history	$172.24M 534,604 shares	0.01%	+11.84K(+2.30%)Added	SEC filing ↗ May 18, 2026	▾
19	RA CAPITAL MANAGEMENT, L.P. CIK 1346824 · View history	$120.43M 373,787 shares	1.28%	0(0.00%)Unchanged	SEC filing ↗ May 15, 2026	▾
20	Hood River Capital Management LLC CIK 1578177 · View history	$115.54M 358,618 shares	1.16%	+69.15K(+23.90%)Added	SEC filing ↗ May 15, 2026	▾

Showing 20 / 293 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

293

Cancelled or null records excluded

Disclosed shares

31,794,895

Not deduplicated across managers

Disclosed value

$10.24B

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Praxis Precision Medicines, Inc. · Q1 2026

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.