Company · Ownership research

Spyre Therapeutics, Inc. SYRE

CIK 0001636282 · CUSIP 00773J202

Insider tradingInitial holdingsInstitutional holders

Quarter-end disclosures, not live holdings.

3 CUSIPs are reported under this ticker. This page covers the one most managers report; the others are not merged in.
This page lists the top 20 of 154 rows by value; the complete set is available through the API.
Some filings reported values in thousands; those figures were scaled ×1000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value
#ManagerValueManager weightChange vs priorSource

Showing 20 / 154 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions
154
Cancelled or null records excluded
Disclosed shares
80,976,884
Not deduplicated across managers
Disclosed value
$2.65B
Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Spyre Therapeutics, Inc. · Q4 2025

Explore all 154 reporting institutions.

This page includes 20 of 154 reporting institutions. Sign in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.

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The initial HTML of this page carries its exact data as script#research-data (JSON): values, units, scope, preview limits and SEC sources. Read it directly, no script or API key needed; script#research-access says what needs an account. This page lists 20 of 154 reporting institutions; totals use the complete disclosed data.

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{"cusip":"00773J202","quarter":"2025Q4","type":"positions","page_size":100}

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.