Spyre Therapeutics, Inc. SYRE
CIK 0001636282 · CUSIP 00773J202
Quarter-end disclosures, not live holdings.
Top 20 institutions
Weight means this stock's share of the manager's own portfolio.
| # | Manager | Value | Manager weight | Change vs prior | Source | |
|---|---|---|---|---|---|---|
| 01 | FMR LLC CIK 315066 · View history | $145.84M 9,038,553 shares | 0.01% | +237.29K(+2.7%)Added | SEC filing ↗ May 12, 2025 | ▾ |
| 02 | Fairmount Funds Management LLC CIK 1802528 · View history | $64.83M 4,018,101 shares | 10.06% | 0(0.0%)Unchanged | SEC filing ↗ May 15, 2025 | ▾ |
| 03 | RTW INVESTMENTS, LP CIK 1493215 · View history | $58.44M 3,621,996 shares | 0.89% | 0(0.0%)Unchanged | SEC filing ↗ May 15, 2025 | ▾ |
| 04 | BlackRock, Inc. CIK 2012383 · View history | $57.65M 3,572,674 shares | 0.00% | +173.08K(+5.1%)Added | SEC filing ↗ May 2, 2025 | ▾ |
| 05 | VANGUARD GROUP INC CIK 102909 · View history | $46.76M 2,898,267 shares | 0.00% | +51.79K(+1.8%)Added | SEC filing ↗ May 9, 2025 | ▾ |
| 06 | Driehaus Capital Management LLC CIK 938206 · View history | $43.84M 2,717,312 shares | 0.42% | -86.34K(-3.1%)Reduced | SEC filing ↗ May 15, 2025 | ▾ |
| 07 | Venrock Adviser, LLC CIK 1615982 · View history | $43.33M 2,685,448 shares | 3.69% | 0(0.0%)Unchanged | SEC filing ↗ May 15, 2025 | ▾ |
| 08 | BRAIDWELL LP CIK 1920938 · View history | $41.60M 2,578,404 shares | 1.46% | 0(0.0%)Unchanged | SEC filing ↗ May 15, 2025 | ▾ |
| 09 | Capital International Investors CIK 1562230 · View history | $38.60M 2,392,541 shares | 0.01% | +2.39MNew | SEC filing ↗ May 12, 2025 | ▾ |
| 10 | PERCEPTIVE ADVISORS LLC CIK 1224962 · Amended · View history | $37.32M 2,313,272 shares | 1.32% | -261.45K(-10.2%)Reduced | SEC filing ↗ Aug 6, 2025 | ▾ |
| 11 | Paradigm Biocapital Advisors LP CIK 1855655 · View history | $34.32M 2,127,205 shares | 1.58% | +600.00K(+39.3%)Added | SEC filing ↗ May 15, 2025 | ▾ |
| 12 | TANG CAPITAL MANAGEMENT LLC CIK 1232621 · View history | $33.08M 2,050,000 shares | 1.83% | +2.05MNew | SEC filing ↗ May 15, 2025 | ▾ |
| 13 | Commodore Capital LP CIK 1831942 · View history | $32.08M 1,988,084 shares | 2.36% | 0(0.0%)Unchanged | SEC filing ↗ May 15, 2025 | ▾ |
| 14 | STATE STREET CORP CIK 93751 · View history | $27.38M 1,697,115 shares | 0.00% | +16.18K(+1.0%)Added | SEC filing ↗ May 15, 2025 | ▾ |
| 15 | WELLINGTON MANAGEMENT GROUP LLP CIK 902219 · View history | $25.71M 1,593,678 shares | 0.00% | -10.83K(-0.7%)Reduced | SEC filing ↗ May 13, 2025 | ▾ |
| 16 | Jefferies Financial Group Inc. CIK 96223 · View history | $20.15M 1,248,854 shares | 0.35% | +31.90K(+2.6%)Added | SEC filing ↗ May 8, 2025 | ▾ |
| 17 | JANUS HENDERSON GROUP PLC CIK 1274173 · View history | $18.68M 1,041,410 shares | 0.01% | -415.33K(-28.5%)Reduced | SEC filing ↗ May 15, 2025 | ▾ |
| 18 | Pictet Asset Management Holding SA CIK 1993888 · View history | $17.25M 1,068,892 shares | 0.02% | -23.23K(-2.1%)Reduced | SEC filing ↗ May 5, 2025 | ▾ |
| 19 | GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history | $17.10M 1,059,563 shares | 0.00% | +93.43K(+9.7%)Added | SEC filing ↗ May 13, 2025 | ▾ |
| 20 | Polar Capital Holdings Plc CIK 1837309 · View history | $13.31M 825,000 shares | 0.08% | +75.00K(+10.0%)Added | SEC filing ↗ May 15, 2025 | ▾ |
Showing 20 / 131 institutions. The complete set is available through the API.
Coverage & totals by quarter
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