PERCEPTIVE ADVISORS LLC
CIK 1224962 · Holdings on Sep 30, 2025 · First reported Nov 14, 2025
Top ten holdings
Q3 2025- RYTM8.33%
- ASND6.25%
- ACLX5.86%
- CELC4.22%
- NUVL3.90%
- MRUS3.68%
- AMLX3.52%
- ROIV3.22%
- MGTX3.00%
- INSM2.92%
Share classes counted separately44.90%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- VRNAWeight decreased · -17.93 pp19.55% → 1.62%Shares -4.98M (-90.48%)
- CELCWeight increased · +3.40 pp0.82% → 4.22%Shares +1.32M (+81.01%)
- RYTMWeight increased · +2.60 pp5.73% → 8.33%Shares +416.69M (+17230.57%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 29
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | RYTMRHYTHM PHARMACEUTICALS INC View history and evidence | $288.39M | 8.33% | 419.10M shares | 5.73% → 8.33%+2.60 pp +416.69M (+17230.57%) | Added | ↗▾ |
| 02 | ASNDASCENDIS PHARMA A/SSPONSORED ADR View history and evidence | $216.40M | 6.25% | 1.09M shares | 6.24% → 6.25%+0.01 pp +124.61K (+12.93%) | Added | ↗▾ |
| 03 | ACLXARCELLX INCCOMMON STOCK View history and evidence | $202.65M | 5.86% | 2.47M shares | 6.12% → 5.86%-0.26 pp -9.65K (-0.39%) | Reduced | ↗▾ |
| 04 | CELCCELCUITY INC View history and evidence | $146.04M | 4.22% | 2.96M shares | 0.82% → 4.22%+3.40 pp +1.32M (+81.01%) | Added | ↗▾ |
| 05 | NUVLNUVALENT INC-A View history and evidence | $135.11M | 3.90% | 1.56M shares | 3.94% → 3.90%-0.04 pp +187.16K (+13.61%) | Added | ↗▾ |
| 06 | MRUSMERUS NV View history and evidence | $127.39M | 3.68% | 1.35M shares | 1.40% → 3.68%+2.28 pp +644.92K (+91.07%) | Added | ↗▾ |
| 07 | AMLXAMYLYX PHARMACEUTICALS INC View history and evidence | $121.66M | 3.52% | 8.95M shares | 1.90% → 3.52%+1.62 pp +1.05M (+13.29%) | Added | ↗▾ |
| 08 | ROIVROIVANT SCIENCES LTDSHS View history and evidence | $111.48M | 3.22% | 7.37M shares | 1.41% → 3.22%+1.81 pp +4.04M (+121.18%) | Added | ↗▾ |
| 09 | MGTXMEIRAGTX HOLDINGS PLC View history and evidence | $103.79M | 3.00% | 12.63M shares | 3.09% → 3.00%-0.09 pp 0 (0.00%) | Unchanged | ↗▾ |
| 10 | INSMINSMED INCCOM PAR $.01 View history and evidence | $101.11M | 2.92% | 702.13K shares | 2.46% → 2.92%+0.46 pp +51.88K (+7.98%) | Added | ↗▾ |
Options overlay 1
$2.01M notionalPut and Call positions are separate. Notional is based on underlying securities, not option premium, market value or net exposure. Quantities are underlying shares.
| Security | Put / Call | Underlying shares | Notional | Quantity change | |
|---|---|---|---|---|---|
SPRYARS PHARMACEUTICALS INC View history and evidence | Put | 200.00K | $2.01M | +200.00K | ▾ |
1 / 1 options · preview only
Exited positions 14
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| SLNO SOLENO THERAPEUTICS INC | Non-derivative | -430,439 | -$36.06M | SEC filing ↗ | SEC filing ↗ |
| XBI SS SPDR S&P BIOTECH ETF | Put | -300,000 | -$24.88M | SEC filing ↗ | SEC filing ↗ |
| EOLS EVOLUS INC | Non-derivative | -2,474,843 | -$22.79M | SEC filing ↗ | SEC filing ↗ |
3 / 14 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 1224962 · Period 2025-09-30
Data loaded 2026-09-23 · First reported 2025-11-14
Amendments and versions
{
"amendments_merged": null,
"prior_versions": null,
"cover_table_value": 3463098749
}Research all 92 reported holdings.
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