SPYRE THERAPEUTICS INC · CUSIP 00773J202 · CIK 1224962
As of 2026-06-30, PERCEPTIVE ADVISORS LLC reported 4.32M SYRE (shares), valued at $383.48M, or 5.95% of its reported non-derivative portfolio. Filed 2026-08-14.
Verify history & sources →Shares increased 14.17%; reported value increased 100.96%, and weight changed +2.18 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds.
Left: % · Right: Shares · Independently scaled axes
Exact data and methodology
Axes scale independently; a crossing does not mean equal values. Weight uses each quarter's total reported non-derivative value. Same CUSIP; missing quarters are gaps, not zero. Revised history may include later disclosures.
| Quarter | Weight | Quantity | Source |
|---|---|---|---|
| Q2 2026 | 5.95% | 4,319,496 | SEC filing ↗Filed Aug 14, 2026 |
| Q1 2026 | 3.77% | 3,783,225 | SEC filing ↗Filed May 29, 2026Amended |
| Q4 2025 | 1.84% | 3,069,225 | SEC filing ↗Filed Feb 17, 2026 |
| Q3 2025 | 0.60% | 1,229,445 | SEC filing ↗Filed Nov 14, 2025 |
| Q2 2025 | 0.86% | 1,529,445 | SEC filing ↗Filed Aug 14, 2025 |
| Q1 2025 | 1.32% | 2,313,272 | SEC filing ↗Filed Aug 6, 2025Amended |
| Q4 2024 | 1.67% | 2,574,723 | SEC filing ↗Filed Feb 14, 2025 |
| Q3 2024 | 1.81% | 2,872,547 | SEC filing ↗Filed Nov 14, 2024 |
| Q2 2024 | 1.72% | 3,031,018 | SEC filing ↗Filed Aug 16, 2024Amended |
| Q1 2024 | 1.71% | 2,556,679 | SEC filing ↗Filed Aug 6, 2024Amended |
| Q4 2023 | 1.25% | 2,606,679 | SEC filing ↗Filed Feb 26, 2024Amended |
| Q3 2023 | 0.03% | 81,116 | SEC filing ↗Filed Nov 14, 2023 |
History & evidence by quarter
| Quarter | Weight | Quantity | Value | Change explained | Source |
|---|---|---|---|---|---|
| Q3 2023 | 0.03% | 81,116 | $993.67K | The prior quarter is outside the free window. Sign in for the comparison. | SEC filing ↗ Filed Nov 14, 2023 |
| Q4 2023 | 1.25% | 2,606,679 | $56.10M | Shares increased 3113.52%; reported value increased 5545.30%, and weight changed +1.22 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Feb 26, 2024 |
| Q1 2024 | 1.71% | 2,556,679 | $96.97M | Shares decreased 1.92%; reported value increased 72.87%, and weight changed +0.46 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Aug 6, 2024 |
| Q2 2024 | 1.72% | 3,031,018 | $71.26M | Shares increased 18.55%; reported value decreased 26.52%, and weight changed +0.01 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Aug 16, 2024 |
| Q3 2024 | 1.81% | 2,872,547 | $84.48M | Shares decreased 5.23%; reported value increased 18.56%, and weight changed +0.09 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Nov 14, 2024 |
| Q4 2024 | 1.67% | 2,574,723 | $59.94M | Shares decreased 10.37%; reported value decreased 29.05%, and weight changed -0.14 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Feb 14, 2025 |
| Q1 2025 | 1.32% | 2,313,272 | $37.32M | Shares decreased 10.15%; reported value decreased 37.73%, and weight changed -0.35 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Aug 6, 2025 |
| Q2 2025 | 0.86% | 1,529,445 | $22.90M | Shares decreased 33.88%; reported value decreased 38.66%, and weight changed -0.46 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Aug 14, 2025 |
| Q3 2025 | 0.60% | 1,229,445 | $20.61M | Shares decreased 19.61%; reported value decreased 10.00%, and weight changed -0.26 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Nov 14, 2025 |
| Q4 2025 | 1.84% | 3,069,225 | $100.55M | Shares increased 149.64%; reported value increased 387.97%, and weight changed +1.24 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Feb 17, 2026 |
| Q1 2026 | 3.77% | 3,783,225 | $190.83M | Shares increased 23.26%; reported value increased 89.79%, and weight changed +1.93 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed May 29, 2026 |
| Q2 2026 | 5.95% | 4,319,496 | $383.48M | Shares increased 14.17%; reported value increased 100.96%, and weight changed +2.18 pp. Weight depends on both the security valuation and total portfolio value, not trade proceeds. | SEC filing ↗ Filed Aug 14, 2026 |
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Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.