Company · Ownership research

Prelude Therapeutics Inc PRLD

CIK 0001678660 · CUSIP 74065P101

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 74065P101 (PRLD), not CUSIP 74065P951 (PRLD), and does not merge CUSIPs.

This page lists the top 20 of 47 rows by value; the complete set is available through the API.

Some filings reported values in thousands; those figures were scaled ×1,000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	ORBIMED ADVISORS LLC CIK 1055951 · View history	$15.71M 10,909,256 shares	0.38%	0(0.00%)Unchanged	SEC filing ↗ Nov 14, 2025	▾
02	BAKER BROS. ADVISORS LP CIK 1263508 · View history	$14.58M 10,123,824 shares	0.11%	0(0.00%)Unchanged	SEC filing ↗ Nov 14, 2025	▾
03	MILLENNIUM MANAGEMENT LLC CIK 1273087 · View history	$1.65M 1,147,044 shares	0.00%	+898.62K(+361.70%)Added	SEC filing ↗ Nov 14, 2025	▾
04	VANGUARD GROUP INC CIK 102909 · View history	$1.43M 992,854 shares	0.00%	+60.28K(+6.50%)Added	SEC filing ↗ Nov 7, 2025	▾
05	PRICE T ROWE ASSOCIATES INC /MD/ CIK 80255 · View history	$1.26M 876,338 shares	0.00%	-51.27K(-5.50%)Reduced	SEC filing ↗ Nov 14, 2025	▾
06	RENAISSANCE TECHNOLOGIES LLC CIK 1037389 · View history	$783.36K 544,000 shares	0.00%	-37.80K(-6.50%)Reduced	SEC filing ↗ Nov 13, 2025	▾
07	ACADIAN ASSET MANAGEMENT LLC CIK 916542 · View history	$777.00K 540,565 shares	0.00%	0(0.00%)Unchanged	SEC filing ↗ Nov 13, 2025	▾
08	MORGAN STANLEY CIK 895421 · Amended · View history	$409.25K 284,203 shares	0.00%	-179(-0.10%)Reduced	SEC filing ↗ May 27, 2026	▾
09	BlackRock, Inc. CIK 2012383 · View history	$381.56K 264,973 shares	0.00%	-167.59K(-38.70%)Reduced	SEC filing ↗ Nov 12, 2025	▾
10	TWO SIGMA ADVISERS, LP CIK 1478735 · View history	$320.69K 222,700 shares	0.00%	-2.30K(-1.00%)Reduced	SEC filing ↗ Nov 14, 2025	▾
11	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$313.37K 217,568 shares	0.00%	0(0.00%)Unchanged	SEC filing ↗ Nov 12, 2025	▾
12	TD Asset Management Inc CIK 1056053 · View history	$231.34K 160,652 shares	0.00%	0(0.00%)Unchanged	SEC filing ↗ Nov 10, 2025	▾
13	TWO SIGMA INVESTMENTS, LP CIK 1179392 · View history	$219.22K 152,233 shares	0.00%	-2.74K(-1.80%)Reduced	SEC filing ↗ Nov 14, 2025	▾
14	Shay Capital LLC CIK 1723643 · View history	$144.00K 100,000 shares	0.03%	+25.00K(+33.30%)Added	SEC filing ↗ Nov 14, 2025	▾
15	STATE STREET CORP CIK 93751 · View history	$140.53K 97,592 shares	0.00%	0(0.00%)Unchanged	SEC filing ↗ Nov 14, 2025	▾
16	GOLDMAN SACHS GROUP INC CIK 886982 · View history	$114.23K 79,327 shares	0.00%	-69.85K(-46.80%)Reduced	SEC filing ↗ Nov 14, 2025	▾
17	GSA CAPITAL PARTNERS LLP CIK 1362033 · View history	$108.00K 75,161 shares	0.01%	+3.78K(+5.30%)Added	SEC filing ↗ Nov 7, 2025	▾
18	MANUFACTURERS LIFE INSURANCE COMPANY, THE CIK 928047 · View history	$99.72K 69,252 shares	0.00%	0(0.00%)Unchanged	SEC filing ↗ Nov 14, 2025	▾
19	BRIDGEWAY CAPITAL MANAGEMENT, LLC CIK 1107261 · View history	$77.04K 53,500 shares	0.00%	-35.00K(-39.50%)Reduced	SEC filing ↗ Nov 14, 2025	▾
20	NORTHERN TRUST CORP CIK 73124 · View history	$52.45K 36,421 shares	0.00%	-1.71K(-4.50%)Reduced	SEC filing ↗ Nov 14, 2025	▾

Showing 20 / 47 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

Cancelled or null records excluded

Disclosed shares

27,162,136

Not deduplicated across managers

Disclosed value

$39.11M

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Prelude Therapeutics Inc · Q3 2025

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This page includes 20 of 47 reporting institutions. Log in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.