Company · Ownership research

Prelude Therapeutics Inc PRLD

CIK 0001678660 · CUSIP 74065P101

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 74065P101 (PRLD), not CUSIP 74065P951 (PRLD), and does not merge CUSIPs.

This page lists the top 20 of 55 rows by value; the complete set is available through the API.

Some filings reported values in thousands; those figures were scaled ×1,000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	ORBIMED ADVISORS LLC CIK 1055951 · View history	$37.31M 10,909,256 shares	0.82%	0(0.00%)Unchanged	SEC filing ↗ May 15, 2026	▾
02	BAKER BROS. ADVISORS LP CIK 1263508 · View history	$34.62M 10,123,824 shares	0.20%	0(0.00%)Unchanged	SEC filing ↗ May 15, 2026	▾
03	Kynam Capital Management, LP CIK 1907884 · View history	$5.45M 1,592,551 shares	0.35%	+803.68K(+101.90%)Added	SEC filing ↗ May 15, 2026	▾
04	VANGUARD CAPITAL MANAGEMENT LLC CIK 2100119 · Amended · View history	$4.21M 1,230,406 shares	0.00%	—	SEC filing ↗ May 15, 2026	▾
05	EcoR1 Capital, LLC CIK 1587114 · View history	$3.24M 947,049 shares	0.14%	+947.05KNew	SEC filing ↗ May 15, 2026	▾
06	TWO SIGMA INVESTMENTS, LP CIK 1179392 · View history	$3.16M 923,626 shares	0.00%	+134.93K(+17.10%)Added	SEC filing ↗ May 15, 2026	▾
07	SPHERA FUNDS MANAGEMENT LTD. CIK 1496201 · View history	$1.91M 558,339 shares	0.33%	+435.59K(+354.90%)Added	SEC filing ↗ May 15, 2026	▾
08	ACADIAN ASSET MANAGEMENT LLC CIK 916542 · View history	$1.75M 511,519 shares	0.00%	-24.18K(-4.50%)Reduced	SEC filing ↗ May 13, 2026	▾
09	MILLENNIUM MANAGEMENT LLC CIK 1273087 · View history	$1.31M 382,737 shares	0.00%	+231.74K(+153.50%)Added	SEC filing ↗ May 15, 2026	▾
10	MARSHALL WACE, LLP CIK 1318757 · View history	$1.23M 358,906 shares	0.00%	+85.02K(+31.00%)Added	SEC filing ↗ May 15, 2026	▾
11	MORGAN STANLEY CIK 895421 · View history	$1.10M 322,161 shares	0.00%	-12.76K(-3.80%)Reduced	SEC filing ↗ May 15, 2026	▾
12	BlackRock, Inc. CIK 2012383 · View history	$1.10M 321,886 shares	0.00%	+55.61K(+20.90%)Added	SEC filing ↗ May 13, 2026	▾
13	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$1.03M 302,458 shares	0.00%	+29.57K(+10.80%)Added	SEC filing ↗ May 15, 2026	▾
14	RENAISSANCE TECHNOLOGIES LLC CIK 1037389 · View history	$941.18K 275,200 shares	0.00%	+3.90K(+1.40%)Added	SEC filing ↗ May 14, 2026	▾
15	SUSQUEHANNA INTERNATIONAL GROUP, LLP CIK 1446194 · View history	$915.84K 267,788 shares	0.00%	+131.88K(+97.00%)Added	SEC filing ↗ May 15, 2026	▾
16	GOLDMAN SACHS GROUP INC CIK 886982 · View history	$808.72K 236,469 shares	0.00%	+118.99K(+101.30%)Added	SEC filing ↗ May 15, 2026	▾
17	JANE STREET GROUP, LLC CIK 1595888 · View history	$659.93K 192,963 shares	0.00%	+81.92K(+73.80%)Added	SEC filing ↗ May 12, 2026	▾
18	VANGUARD FIDUCIARY TRUST CO CIK 933478 · Amended · View history	$538.24K 157,380 shares	0.00%	—	SEC filing ↗ May 8, 2026	▾
19	ADAR1 Capital Management, LLC CIK 1940272 · View history	$522.66K 152,825 shares	0.03%	+152.82KNew	SEC filing ↗ May 18, 2026	▾
20	STATE STREET CORP CIK 93751 · View history	$472.75K 138,231 shares	0.00%	+10.94K(+8.60%)Added	SEC filing ↗ May 15, 2026	▾

Showing 20 / 55 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

Cancelled or null records excluded

Disclosed shares

30,772,416

Not deduplicated across managers

Disclosed value

$105.24M

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Prelude Therapeutics Inc · Q1 2026

Explore all 55 reporting institutions.

This page includes 20 of 55 reporting institutions. Log in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.

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Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.