Company · Ownership research

Prelude Therapeutics Inc PRLD

CIK 0001678660 · CUSIP 74065P101

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 74065P101 (PRLD), not CUSIP 74065P951 (PRLD), and does not merge CUSIPs.

This page lists the top 20 of 48 rows by value; the complete set is available through the API.

Some filings reported values in thousands; those figures were scaled ×1,000 to dollars.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	ORBIMED ADVISORS LLC CIK 1055951 · View history	$31.64M 10,909,256 shares	0.65%	0(0.00%)Unchanged	SEC filing ↗ Feb 17, 2026	▾
02	BAKER BROS. ADVISORS LP CIK 1263508 · View history	$29.36M 10,123,824 shares	0.17%	0(0.00%)Unchanged	SEC filing ↗ Feb 17, 2026	▾
03	VANGUARD GROUP INC CIK 102909 · View history	$4.10M 1,413,986 shares	0.00%	+421.13K(+42.40%)Added	SEC filing ↗ Jan 29, 2026	▾
04	Kynam Capital Management, LP CIK 1907884 · View history	$2.29M 788,867 shares	0.15%	+788.87KNew	SEC filing ↗ Feb 17, 2026	▾
05	TWO SIGMA INVESTMENTS, LP CIK 1179392 · View history	$2.29M 788,695 shares	0.00%	+636.46K(+418.10%)Added	SEC filing ↗ Feb 17, 2026	▾
06	PRICE T ROWE ASSOCIATES INC /MD/ CIK 80255 · View history	$2.19M 755,956 shares	0.00%	-120.38K(-13.70%)Reduced	SEC filing ↗ Feb 17, 2026	▾
07	ACADIAN ASSET MANAGEMENT LLC CIK 916542 · View history	$1.55M 535,703 shares	0.00%	-4.86K(-0.90%)Reduced	SEC filing ↗ Feb 10, 2026	▾
08	MORGAN STANLEY CIK 895421 · Amended · View history	$971.26K 334,916 shares	0.00%	+50.71K(+17.80%)Added	SEC filing ↗ May 27, 2026	▾
09	MARSHALL WACE, LLP CIK 1318757 · View history	$794.26K 273,883 shares	0.00%	+273.88KNew	SEC filing ↗ Feb 13, 2026	▾
10	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$791.50K 272,886 shares	0.00%	+55.32K(+25.40%)Added	SEC filing ↗ Feb 9, 2026	▾
11	RENAISSANCE TECHNOLOGIES LLC CIK 1037389 · View history	$786.77K 271,300 shares	0.00%	-272.70K(-50.10%)Reduced	SEC filing ↗ Feb 12, 2026	▾
12	BlackRock, Inc. CIK 2012383 · View history	$772.21K 266,280 shares	0.00%	+1.31K(+0.50%)Added	SEC filing ↗ Feb 12, 2026	▾
13	TWO SIGMA ADVISERS, LP CIK 1478735 · View history	$688.17K 237,300 shares	0.00%	+14.60K(+6.60%)Added	SEC filing ↗ Feb 17, 2026	▾
14	TD Asset Management Inc CIK 1056053 · View history	$465.89K 160,652 shares	0.00%	0(0.00%)Unchanged	SEC filing ↗ Feb 10, 2026	▾
15	MILLENNIUM MANAGEMENT LLC CIK 1273087 · View history	$437.89K 150,997 shares	0.00%	-996.05K(-86.80%)Reduced	SEC filing ↗ Feb 17, 2026	▾
16	SUSQUEHANNA INTERNATIONAL GROUP, LLP CIK 1446194 · View history	$394.14K 135,909 shares	0.00%	+135.91KNew	SEC filing ↗ Feb 17, 2026	▾
17	STATE STREET CORP CIK 93751 · View history	$369.15K 127,292 shares	0.00%	+29.70K(+30.40%)Added	SEC filing ↗ Feb 13, 2026	▾
18	SPHERA FUNDS MANAGEMENT LTD. CIK 1496201 · View history	$355.98K 122,752 shares	0.07%	+122.75KNew	SEC filing ↗ Feb 17, 2026	▾
19	GOLDMAN SACHS GROUP INC CIK 886982 · Amended · View history	$340.68K 117,477 shares	0.00%	+38.15K(+48.10%)Added	SEC filing ↗ Mar 25, 2026	▾
20	JANE STREET GROUP, LLC CIK 1595888 · View history	$322.02K 111,040 shares	0.00%	+76.22K(+218.90%)Added	SEC filing ↗ Feb 12, 2026	▾

Showing 20 / 48 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

Cancelled or null records excluded

Disclosed shares

28,472,315

Not deduplicated across managers

Disclosed value

$82.56M

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Prelude Therapeutics Inc · Q4 2025

Explore all 48 reporting institutions.

This page includes 20 of 48 reporting institutions. Log in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.

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Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.