Company · Ownership research

Septerna, Inc. SEPN

CIK 0001984086 · CUSIP 81734D104

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 81734D104 (SEPN), not CUSIP 81734D904 (SEPN), CUSIP 81734D954 (SEPN), and does not merge CUSIPs.

This page lists the top 20 of 72 rows by value; the complete set is available through the API.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	RA CAPITAL MANAGEMENT, L.P. CIK 1346824 · View history	$40.51M 6,995,858 shares	0.68%	0(0.00%)Unchanged	SEC filing ↗ May 15, 2025	▾
02	TRV GP V, LLC CIK 1990717 · View history	$35.99M 6,215,591 shares	28.77%	0(0.00%)Unchanged	SEC filing ↗ May 9, 2025	▾
03	BVF INC/IL CIK 1056807 · View history	$25.45M 4,396,124 shares	1.04%	+1.94M(+79.30%)Added	SEC filing ↗ May 15, 2025	▾
04	TRV GP VI, LLC CIK 1990716 · View history	$24.39M 4,211,659 shares	58.10%	+1.06M(+33.60%)Added	SEC filing ↗ May 9, 2025	▾
05	Samsara BioCapital, LLC CIK 1744967 · View history	$18.23M 3,149,128 shares	3.25%	+380.61K(+13.70%)Added	SEC filing ↗ May 15, 2025	▾
06	Driehaus Capital Management LLC CIK 938206 · View history	$18.08M 3,122,608 shares	0.17%	+533.05K(+20.60%)Added	SEC filing ↗ May 15, 2025	▾
07	Siren, L.L.C. CIK 2005245 · Amended · View history	$12.75M 2,202,514 shares	0.72%	0(0.00%)Unchanged	SEC filing ↗ May 23, 2025	▾
08	Deep Track Capital, LP CIK 1856083 · View history	$11.08M 1,912,929 shares	0.36%	0(0.00%)Unchanged	SEC filing ↗ May 15, 2025	▾
09	GOLDMAN SACHS GROUP INC CIK 886982 · Amended · View history	$8.39M 1,449,399 shares	0.00%	-224.96K(-13.40%)Reduced	SEC filing ↗ May 16, 2025	▾
10	Avoro Capital Advisors LLC CIK 1633313 · View history	$7.74M 1,337,500 shares	0.12%	+227.50K(+20.50%)Added	SEC filing ↗ May 15, 2025	▾
11	BlackRock, Inc. CIK 2012383 · View history	$7.29M 1,258,313 shares	0.00%	-418.82K(-25.00%)Reduced	SEC filing ↗ May 2, 2025	▾
12	Catalio Capital Management, LP CIK 1958125 · View history	$5.93M 1,024,245 shares	1.47%	0(0.00%)Unchanged	SEC filing ↗ May 15, 2025	▾
13	VANGUARD GROUP INC CIK 102909 · View history	$5.76M 995,044 shares	0.00%	+10.01K(+1.00%)Added	SEC filing ↗ May 9, 2025	▾
14	Checkpoint Capital L.P. CIK 1977548 · View history	$4.78M 824,878 shares	2.62%	+824.88KNew	SEC filing ↗ May 15, 2025	▾
15	Sio Capital Management, LLC CIK 1482416 · View history	$4.57M 788,670 shares	1.38%	+516.98K(+190.30%)Added	SEC filing ↗ May 15, 2025	▾
16	Soleus Capital Management, L.P. CIK 1802630 · View history	$4.35M 751,353 shares	0.34%	+75.94K(+11.20%)Added	SEC filing ↗ May 15, 2025	▾
17	ADAR1 Capital Management, LLC CIK 1940272 · View history	$4.17M 720,848 shares	0.80%	+720.85KNew	SEC filing ↗ May 15, 2025	▾
18	Woodline Partners LP CIK 1784547 · View history	$3.37M 582,585 shares	0.02%	+282.58K(+94.20%)Added	SEC filing ↗ May 15, 2025	▾
19	Casdin Capital, LLC CIK 1534261 · View history	$3.20M 553,268 shares	0.26%	0(0.00%)Unchanged	SEC filing ↗ May 15, 2025	▾
20	MILLENNIUM MANAGEMENT LLC CIK 1273087 · View history	$2.53M 436,564 shares	0.00%	+436.56KNew	SEC filing ↗ May 15, 2025	▾

Showing 20 / 72 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

Cancelled or null records excluded

Disclosed shares

45,290,478

Not deduplicated across managers

Disclosed value

$262.25M

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Septerna, Inc. · Q1 2025

Explore all 72 reporting institutions.

This page includes 20 of 72 reporting institutions. Log in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.