Company · Ownership research

Septerna, Inc. SEPN

CIK 0001984086 · CUSIP 81734D104

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 81734D104 (SEPN), not CUSIP 81734D904 (SEPN), CUSIP 81734D954 (SEPN), and does not merge CUSIPs.

This page lists the top 20 of 90 rows by value; the complete set is available through the API.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	RA CAPITAL MANAGEMENT, L.P. CIK 1346824 · View history	$73.95M 6,995,858 shares	1.25%	0(0.00%)Unchanged	SEC filing ↗ Aug 14, 2025	▾
02	TRV GP V, LLC CIK 1990717 · View history	$65.70M 6,215,591 shares	39.66%	0(0.00%)Unchanged	SEC filing ↗ Aug 8, 2025	▾
03	Driehaus Capital Management LLC CIK 938206 · View history	$49.47M 4,680,431 shares	0.40%	+1.56M(+49.90%)Added	SEC filing ↗ Aug 14, 2025	▾
04	BVF INC/IL CIK 1056807 · View history	$46.47M 4,396,124 shares	1.66%	0(0.00%)Unchanged	SEC filing ↗ Aug 14, 2025	▾
05	TRV GP VI, LLC CIK 1990716 · View history	$44.52M 4,211,659 shares	69.32%	0(0.00%)Unchanged	SEC filing ↗ Aug 8, 2025	▾
06	Samsara BioCapital, LLC CIK 1744967 · View history	$33.29M 3,149,128 shares	6.81%	0(0.00%)Unchanged	SEC filing ↗ Aug 14, 2025	▾
07	Siren, L.L.C. CIK 2005245 · View history	$23.28M 2,202,514 shares	1.20%	0(0.00%)Unchanged	SEC filing ↗ Aug 13, 2025	▾
08	GOLDMAN SACHS GROUP INC CIK 886982 · View history	$14.97M 1,416,314 shares	0.00%	-33.09K(-2.30%)Reduced	SEC filing ↗ Aug 14, 2025	▾
09	VANGUARD GROUP INC CIK 102909 · View history	$14.95M 1,414,363 shares	0.00%	+419.32K(+42.10%)Added	SEC filing ↗ Aug 11, 2025	▾
10	BlackRock, Inc. CIK 2012383 · View history	$14.70M 1,390,800 shares	0.00%	+132.49K(+10.50%)Added	SEC filing ↗ Aug 12, 2025	▾
11	Avoro Capital Advisors LLC CIK 1633313 · View history	$13.08M 1,237,500 shares	0.23%	-100.00K(-7.50%)Reduced	SEC filing ↗ Aug 14, 2025	▾
12	ADAR1 Capital Management, LLC CIK 1940272 · View history	$8.96M 847,227 shares	1.45%	+126.38K(+17.50%)Added	SEC filing ↗ Aug 14, 2025	▾
13	Checkpoint Capital L.P. CIK 1977548 · View history	$6.20M 586,473 shares	2.89%	-238.41K(-28.90%)Reduced	SEC filing ↗ Aug 14, 2025	▾
14	Sio Capital Management, LLC CIK 1482416 · View history	$6.18M 584,435 shares	2.48%	-204.24K(-25.90%)Reduced	SEC filing ↗ Aug 13, 2025	▾
15	Casdin Capital, LLC CIK 1534261 · View history	$5.85M 553,268 shares	0.53%	0(0.00%)Unchanged	SEC filing ↗ Aug 14, 2025	▾
16	PERCEPTIVE ADVISORS LLC CIK 1224962 · View history	$5.72M 541,450 shares	0.21%	+541.45KNew	SEC filing ↗ Aug 14, 2025	▾
17	VR Adviser, LLC CIK 1615982 · View history	$5.71M 540,453 shares	0.43%	+540.45KNew	SEC filing ↗ Aug 14, 2025	▾
18	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$5.16M 487,956 shares	0.00%	+78.32K(+19.10%)Added	SEC filing ↗ Aug 8, 2025	▾
19	STATE STREET CORP CIK 93751 · View history	$3.91M 369,992 shares	0.00%	+25.39K(+7.40%)Added	SEC filing ↗ Aug 14, 2025	▾
20	Catalio Capital Management, LP CIK 1958125 · View history	$3.11M 294,360 shares	0.65%	-729.88K(-71.30%)Reduced	SEC filing ↗ Aug 14, 2025	▾

Showing 20 / 90 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

Cancelled or null records excluded

Disclosed shares

44,430,474

Not deduplicated across managers

Disclosed value

$469.63M

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Septerna, Inc. · Q2 2025

Explore all 90 reporting institutions.

This page includes 20 of 90 reporting institutions. Log in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.