Company · Ownership research

Septerna, Inc. SEPN

CIK 0001984086 · CUSIP 81734D104

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 81734D104 (SEPN), not CUSIP 81734D904 (SEPN), CUSIP 81734D954 (SEPN), and does not merge CUSIPs.

This page lists the top 20 of 82 rows by value; the complete set is available through the API.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	RA CAPITAL MANAGEMENT, L.P. CIK 1346824 · View history	$131.59M 6,995,858 shares	1.62%	0(0.00%)Unchanged	SEC filing ↗ Nov 14, 2025	▾
02	TRV GP V, LLC CIK 1990717 · View history	$116.92M 6,215,591 shares	33.07%	0(0.00%)Unchanged	SEC filing ↗ Nov 13, 2025	▾
03	Driehaus Capital Management LLC CIK 938206 · View history	$92.54M 4,919,896 shares	0.66%	+239.47K(+5.10%)Added	SEC filing ↗ Nov 14, 2025	▾
04	TRV GP VI, LLC CIK 1990716 · View history	$79.22M 4,211,659 shares	72.26%	0(0.00%)Unchanged	SEC filing ↗ Nov 13, 2025	▾
05	BVF INC/IL CIK 1056807 · View history	$75.54M 4,015,790 shares	3.06%	-380.33K(-8.70%)Reduced	SEC filing ↗ Nov 14, 2025	▾
06	Samsara BioCapital, LLC CIK 1744967 · View history	$59.24M 3,149,128 shares	7.73%	0(0.00%)Unchanged	SEC filing ↗ Nov 14, 2025	▾
07	Siren, L.L.C. CIK 2005245 · View history	$41.43M 2,202,514 shares	1.62%	0(0.00%)Unchanged	SEC filing ↗ Nov 13, 2025	▾
08	VANGUARD GROUP INC CIK 102909 · View history	$28.57M 1,518,757 shares	0.00%	+104.39K(+7.40%)Added	SEC filing ↗ Nov 7, 2025	▾
09	BlackRock, Inc. CIK 2012383 · View history	$27.46M 1,459,795 shares	0.00%	+69.00K(+5.00%)Added	SEC filing ↗ Nov 12, 2025	▾
10	GOLDMAN SACHS GROUP INC CIK 886982 · View history	$27.36M 1,454,720 shares	0.00%	+38.41K(+2.70%)Added	SEC filing ↗ Nov 14, 2025	▾
11	Avoro Capital Advisors LLC CIK 1633313 · View history	$25.16M 1,337,500 shares	0.33%	+100.00K(+8.10%)Added	SEC filing ↗ Nov 14, 2025	▾
12	ADAR1 Capital Management, LLC CIK 1940272 · View history	$22.13M 1,176,491 shares	2.19%	+329.26K(+38.90%)Added	SEC filing ↗ Nov 14, 2025	▾
13	VR Adviser, LLC CIK 1615982 · View history	$11.49M 610,808 shares	0.65%	+70.36K(+13.00%)Added	SEC filing ↗ Nov 14, 2025	▾
14	Casdin Capital, LLC CIK 1534261 · View history	$10.41M 553,268 shares	0.87%	0(0.00%)Unchanged	SEC filing ↗ Nov 14, 2025	▾
15	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$10.27M 545,701 shares	0.00%	+57.74K(+11.80%)Added	SEC filing ↗ Nov 12, 2025	▾
16	PERCEPTIVE ADVISORS LLC CIK 1224962 · View history	$10.18M 541,450 shares	0.29%	0(0.00%)Unchanged	SEC filing ↗ Nov 14, 2025	▾
17	STATE STREET CORP CIK 93751 · View history	$7.88M 418,960 shares	0.00%	+48.97K(+13.20%)Added	SEC filing ↗ Nov 14, 2025	▾
18	MILLENNIUM MANAGEMENT LLC CIK 1273087 · View history	$7.23M 384,200 shares	0.01%	+332.26K(+639.60%)Added	SEC filing ↗ Nov 14, 2025	▾
19	Catalio Capital Management, LP CIK 1958125 · View history	$5.54M 294,360 shares	1.02%	0(0.00%)Unchanged	SEC filing ↗ Nov 14, 2025	▾
20	Checkpoint Capital L.P. CIK 1977548 · View history	$5.33M 283,158 shares	1.78%	-303.31K(-51.70%)Reduced	SEC filing ↗ Nov 14, 2025	▾

Showing 20 / 82 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

Cancelled or null records excluded

Disclosed shares

44,549,033

Not deduplicated across managers

Disclosed value

$837.97M

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Septerna, Inc. · Q3 2025

Explore all 82 reporting institutions.

This page includes 20 of 82 reporting institutions. Log in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.