Company · Ownership research

Septerna, Inc. SEPN

CIK 0001984086 · CUSIP 81734D104

Insider trading Initial holdings Institutional holders

Quarter-end disclosures, not live holdings.

Several CUSIPs are reported for this company; this page shows CUSIP 81734D104 (SEPN), not CUSIP 81734D904 (SEPN), CUSIP 81734D954 (SEPN), and does not merge CUSIPs.

This page lists the top 20 of 122 rows by value; the complete set is available through the API.

Top 20 institutions

Weight means this stock's share of the manager's own portfolio.

By reported value

#	Manager	Value	Manager weight	Change vs prior	Source
01	RA CAPITAL MANAGEMENT, L.P. CIK 1346824 · View history	$195.04M 6,995,858 shares	2.00%	0(0.00%)Unchanged	SEC filing ↗ Feb 17, 2026	▾
02	TRV GP V, LLC CIK 1990717 · View history	$173.29M 6,215,591 shares	40.38%	0(0.00%)Unchanged	SEC filing ↗ Feb 13, 2026	▾
03	Driehaus Capital Management LLC CIK 938206 · View history	$134.09M 4,809,470 shares	0.91%	-110.43K(-2.20%)Reduced	SEC filing ↗ Feb 17, 2026	▾
04	TRV GP VI, LLC CIK 1990716 · View history	$117.42M 4,211,659 shares	79.05%	0(0.00%)Unchanged	SEC filing ↗ Feb 13, 2026	▾
05	Samsara BioCapital, LLC CIK 1744967 · View history	$87.80M 3,149,128 shares	9.06%	0(0.00%)Unchanged	SEC filing ↗ Feb 17, 2026	▾
06	GOLDMAN SACHS GROUP INC CIK 886982 · Amended · View history	$75.70M 2,715,129 shares	0.01%	+1.26M(+86.60%)Added	SEC filing ↗ Mar 25, 2026	▾
07	Siren, L.L.C. CIK 2005245 · View history	$55.76M 2,000,000 shares	1.66%	-202.51K(-9.20%)Reduced	SEC filing ↗ Feb 13, 2026	▾
08	BlackRock, Inc. CIK 2012383 · View history	$50.22M 1,801,328 shares	0.00%	+341.53K(+23.40%)Added	SEC filing ↗ Feb 12, 2026	▾
09	BVF INC/IL CIK 1056807 · View history	$47.98M 1,720,782 shares	1.61%	-2.30M(-57.10%)Reduced	SEC filing ↗ Feb 17, 2026	▾
10	VANGUARD GROUP INC CIK 102909 · View history	$42.05M 1,508,195 shares	0.00%	-10.56K(-0.70%)Reduced	SEC filing ↗ Jan 29, 2026	▾
11	Avoro Capital Advisors LLC CIK 1633313 · Amended · View history	$37.29M 1,337,500 shares	0.37%	0(0.00%)Unchanged	SEC filing ↗ Mar 16, 2026	▾
12	ADAR1 Capital Management, LLC CIK 1940272 · Amended · View history	$32.27M 1,157,611 shares	2.41%	-18.88K(-1.60%)Reduced	SEC filing ↗ Feb 18, 2026	▾
13	First Light Asset Management, LLC CIK 1600004 · View history	$17.31M 620,811 shares	1.32%	+620.81KNew	SEC filing ↗ Feb 17, 2026	▾
14	VR Adviser, LLC CIK 1615982 · View history	$17.03M 610,808 shares	0.84%	0(0.00%)Unchanged	SEC filing ↗ Feb 17, 2026	▾
15	GEODE CAPITAL MANAGEMENT, LLC CIK 1214717 · View history	$15.97M 572,734 shares	0.00%	+27.03K(+5.00%)Added	SEC filing ↗ Feb 9, 2026	▾
16	Casdin Capital, LLC CIK 1534261 · View history	$15.43M 553,268 shares	0.96%	0(0.00%)Unchanged	SEC filing ↗ Feb 17, 2026	▾
17	PRIMECAP MANAGEMENT CO/CA/ CIK 763212 · View history	$15.23M 546,100 shares	0.01%	+546.10KNew	SEC filing ↗ Feb 11, 2026	▾
18	STATE STREET CORP CIK 93751 · View history	$15.06M 540,028 shares	0.00%	+121.07K(+28.90%)Added	SEC filing ↗ Feb 13, 2026	▾
19	PERCEPTIVE ADVISORS LLC CIK 1224962 · View history	$12.08M 433,160 shares	0.22%	-108.29K(-20.00%)Reduced	SEC filing ↗ Feb 17, 2026	▾
20	Woodline Partners LP CIK 1784547 · View history	$10.74M 385,310 shares	0.04%	+102.72K(+36.40%)Added	SEC filing ↗ Feb 17, 2026	▾

Showing 20 / 122 institutions. The complete set is available through the API.

Coverage & totals by quarter

Reporting institutions

122

Cancelled or null records excluded

Disclosed shares

45,588,030

Not deduplicated across managers

Disclosed value

$1.27B

Not market cap or free float

Reporting institutions by quarter

Counts also change with data coverage and reporting entities; they do not measure net buying. Distinct managers with a live stock row in this CUSIP; totals may include overlapping filings and are not a share of the company.

Septerna, Inc. · Q4 2025

Explore all 122 reporting institutions.

This page includes 20 of 122 reporting institutions. Log in to look up the full history beyond 3 years, use advanced screening & filtering, download CSV, and get the complete set through the Akkru API.

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Sources, coverage & how to read this data

Figures are as reported to the SEC and merged with later amendments where Akkru could match them. Preview limits apply to what is listed, not to the totals, which come from the complete reported data. Nothing is zero-filled: a missing quarter or month is shown as missing.