EcoR1 Capital, LLC
CIK 1587114 · Holdings on Dec 31, 2024 · First reported Feb 14, 2025
Top ten holdings
Q4 2024- APLS15.16%
- ZYME8.79%
- CRNX8.76%
- JAZZ8.40%
- PRTA6.41%
- XNCR5.64%
- ARVN5.15%
- ANAB4.17%
- SRPT3.74%
- JANX3.14%
Share classes counted separately69.36%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- ANABWeight decreased · -4.77 pp8.94% → 4.17%Shares +78.45K (+1.01%)
- APLSWeight increased · +3.41 pp11.75% → 15.16%Shares 0 (0.00%)
- ZYMEWeight increased · +3.01 pp5.78% → 8.79%Shares +1.59M (+11.84%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 26
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | APLSAPELLIS PHARMACEUTICALS INC View history and evidence | $379.44M | 15.16% | 11.89M shares | 11.75% → 15.16%+3.41 pp 0 (0.00%) | Unchanged | ↗▾ |
| 02 | ZYMEZYMEWORKS INC View history and evidence | $220.01M | 8.79% | 15.03M shares | 5.78% → 8.79%+3.01 pp +1.59M (+11.84%) | Added | ↗▾ |
| 03 | CRNXCRINETICS PHARMACEUTICALS IN View history and evidence | $219.25M | 8.76% | 4.29M shares | 7.51% → 8.76%+1.25 pp 0 (0.00%) | Unchanged | ↗▾ |
| 04 | JAZZJAZZ PHARMACEUTICALS PLCSHS USD View history and evidence | $210.15M | 8.40% | 1.71M shares | 6.51% → 8.40%+1.89 pp 0 (0.00%) | Unchanged | ↗▾ |
| 05 | PRTAPROTHENA CORP PLCSHS View history and evidence | $160.44M | 6.41% | 11.58M shares | 6.64% → 6.41%-0.23 pp 0 (0.00%) | Unchanged | ↗▾ |
| 06 | XNCRXENCOR INC View history and evidence | $141.21M | 5.64% | 6.14M shares | 3.67% → 5.64%+1.97 pp +814.35K (+15.28%) | Added | ↗▾ |
| 07 | ARVNARVINAS INC View history and evidence | $128.95M | 5.15% | 6.73M shares | 5.67% → 5.15%-0.52 pp 0 (0.00%) | Unchanged | ↗▾ |
| 08 | ANABANAPTYSBIO INC View history and evidence | $104.24M | 4.17% | 7.87M shares | 8.94% → 4.17%-4.77 pp +78.45K (+1.01%) | Added | ↗▾ |
| 09 | SRPTSAREPTA THERAPEUTICS INC View history and evidence | $93.62M | 3.74% | 770.00K shares | Prior unavailable +770.00K | New | ↗▾ |
| 10 | JANXJANUX THERAPEUTICS INC View history and evidence | $78.69M | 3.14% | 1.47M shares | 2.29% → 3.14%+0.85 pp 0 (0.00%) | Unchanged | ↗▾ |
Options overlay 4
$141.62M notionalPut and Call positions are separate. Notional is based on underlying securities, not option premium, market value or net exposure. Quantities are underlying shares.
| Security | Put / Call | Underlying shares | Notional | Quantity change | |
|---|---|---|---|---|---|
PFEPFIZER INC View history and evidence | Call | 5.00M | $132.65M | +5.00M | ▾ |
QUREUNIQURE NVSHS View history and evidence | Call | 385.00K | $6.80M | +385.00K | ▾ |
ETONETON PHARMACEUTICALS INC View history and evidence | Call | 151.40K | $2.02M | -76.60K (-33.60%) | ▾ |
3 / 4 options · preview only
Exited positions 16
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| CNTA CENTESSA PHARMACEUTICALS-ADR | Non-derivative | -3,223,851 | -$51.55M | SEC filing ↗ | SEC filing ↗ |
| VRDN VIRIDIAN THERAPEUTICS INC | Non-derivative | -1,958,847 | -$44.56M | SEC filing ↗ | SEC filing ↗ |
| NUVB NUVATION BIO INC | Non-derivative | -19,209,643 | -$43.99M | SEC filing ↗ | SEC filing ↗ |
3 / 16 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 1587114 · Period 2024-12-31
Data loaded 2026-09-23 · First reported 2025-02-14
Amendments and versions
{
"amendments_merged": null,
"prior_versions": null,
"cover_table_value": 2645070547
}Research all 59 reported holdings.
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