EcoR1 Capital, LLC
CIK 1587114 · Holdings on Sep 30, 2025 · First reported Nov 14, 2025
Top ten holdings
Q3 2025- ZYME18.83%
- ANAB11.58%
- QURE11.18%
- JAZZ10.80%
- CRNX8.57%
- CRSP4.32%
- TNGX4.29%
- ORIC3.88%
- APLS3.75%
- XNCR3.46%
Share classes counted separately80.66%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- APLSWeight decreased · -8.45 pp12.20% → 3.75%Shares -8.45M (-71.02%)
- QUREWeight increased · +7.88 pp3.30% → 11.18%Shares 0 (0.00%)
- ORICWeight increased · +2.91 pp0.97% → 3.88%Shares +5.11M (+315.81%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 30
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | ZYMEZYMEWORKS INC View history and evidence | $392.33M | 18.83% | 22.97M shares | 17.08% → 18.83%+1.75 pp 0 (0.00%) | Unchanged | ↗▾ |
| 02 | ANABANAPTYSBIO INC View history and evidence | $241.29M | 11.58% | 7.88M shares | 10.37% → 11.58%+1.21 pp 0 (0.00%) | Unchanged | ↗▾ |
| 03 | QUREUNIQURE NVSHS View history and evidence | $232.84M | 11.18% | 3.99M shares | 3.30% → 11.18%+7.88 pp 0 (0.00%) | Unchanged | ↗▾ |
| 04 | JAZZJAZZ PHARMACEUTICALS PLCSHS USD View history and evidence | $224.91M | 10.80% | 1.71M shares | 10.73% → 10.80%+0.07 pp 0 (0.00%) | Unchanged | ↗▾ |
| 05 | CRNXCRINETICS PHARMACEUTICALS IN View history and evidence | $178.60M | 8.57% | 4.29M shares | 7.31% → 8.57%+1.26 pp 0 (0.00%) | Unchanged | ↗▾ |
| 06 | CRSPCRISPR THERAPEUTICS AGNAMEN AKT View history and evidence | $90.04M | 4.32% | 1.39M shares | 4.00% → 4.32%+0.32 pp 0 (0.00%) | Unchanged | ↗▾ |
| 07 | TNGXTANGO THERAPEUTICS INC View history and evidence | $89.30M | 4.29% | 10.63M shares | 3.23% → 4.29%+1.06 pp 0 (0.00%) | Unchanged | ↗▾ |
| 08 | ORICORIC PHARMACEUTICALS INC View history and evidence | $80.74M | 3.88% | 6.73M shares | 0.97% → 3.88%+2.91 pp +5.11M (+315.81%) | Added | ↗▾ |
| 09 | APLSAPELLIS PHARMACEUTICALS INC View history and evidence | $78.01M | 3.75% | 3.45M shares | 12.20% → 3.75%-8.45 pp -8.45M (-71.02%) | Reduced | ↗▾ |
| 10 | XNCRXENCOR INC View history and evidence | $72.08M | 3.46% | 6.14M shares | 2.86% → 3.46%+0.60 pp 0 (0.00%) | Unchanged | ↗▾ |
Options overlay 0
No options reported this quarter.
Exited positions 13
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| 46565G104 ITEOS THERAPEUTICS INC | Non-derivative | -10,688,978 | -$106.57M | SEC filing ↗ | SEC filing ↗ |
| JANX JANUX THERAPEUTICS INC | Non-derivative | -1,469,818 | -$33.95M | SEC filing ↗ | SEC filing ↗ |
| AKRO AKERO THERAPEUTICS INC | Non-derivative | -440,000 | -$23.48M | SEC filing ↗ | SEC filing ↗ |
3 / 13 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 1587114 · Period 2025-09-30
Data loaded 2026-09-23 · First reported 2025-11-14
Amendments and versions
{
"amendments_merged": null,
"prior_versions": null,
"cover_table_value": 2083868932
}Take these holdings further.
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