EcoR1 Capital, LLC
CIK 1587114 · Holdings on Dec 31, 2025 · First reported Feb 17, 2026
Top ten holdings
Q4 2025- ZYME27.61%
- ANAB17.44%
- JAZZ13.24%
- CRNX9.11%
- CNTA3.56%
- CRSP3.33%
- MBX3.06%
- IMNM2.80%
- ORIC2.51%
- LKFT2.49%
Share classes counted separately85.15%
Portfolio value by quarter
What changed this quarter?
Within preview · weight change- ZYMEWeight increased · +8.78 pp18.83% → 27.61%Shares 0 (0.00%)
- ANABWeight increased · +5.86 pp11.58% → 17.44%Shares 0 (0.00%)
- CNTAWeight increased · +2.92 pp0.64% → 3.56%Shares +2.56M (+466.36%)
Weight = security value ÷ total reported holdings value. Changes are in percentage points; price moves also affect weights, so they are not trade sizes.
Top 10 holdings 28
USD · B = billion · M = million; expand a row for exact values| # | Security | Value | Weight | Quantity | Weight / quantity change | Activity | |
|---|---|---|---|---|---|---|---|
| 01 | ZYMEZYMEWORKS INC View history and evidence | $604.81M | 27.61% | 22.97M shares | 18.83% → 27.61%+8.78 pp 0 (0.00%) | Unchanged | ↗▾ |
| 02 | ANABANAPTYSBIO INC View history and evidence | $382.03M | 17.44% | 7.88M shares | 11.58% → 17.44%+5.86 pp 0 (0.00%) | Unchanged | ↗▾ |
| 03 | JAZZJAZZ PHARMACEUTICALS PLCSHS USD View history and evidence | $290.10M | 13.24% | 1.71M shares | 10.80% → 13.24%+2.44 pp 0 (0.00%) | Unchanged | ↗▾ |
| 04 | CRNXCRINETICS PHARMACEUTICALS IN View history and evidence | $199.61M | 9.11% | 4.29M shares | 8.57% → 9.11%+0.54 pp 0 (0.00%) | Unchanged | ↗▾ |
| 05 | CNTACENTESSA PHARMACEUTICALS-ADRSPONSORED ADS View history and evidence | $77.91M | 3.56% | 3.12M shares | 0.64% → 3.56%+2.92 pp +2.56M (+466.36%) | Added | ↗▾ |
| 06 | CRSPCRISPR THERAPEUTICS AGNAMEN AKT View history and evidence | $72.85M | 3.33% | 1.39M shares | 4.32% → 3.33%-0.99 pp 0 (0.00%) | Unchanged | ↗▾ |
| 07 | MBXMBX BIOSCIENCES INC View history and evidence | $66.98M | 3.06% | 2.12M shares | 1.78% → 3.06%+1.28 pp 0 (0.00%) | Unchanged | ↗▾ |
| 08 | IMNMIMMUNOME INC View history and evidence | $61.34M | 2.80% | 2.86M shares | 2.29% → 2.80%+0.51 pp -1.22M (-30.00%) | Reduced | ↗▾ |
| 09 | ORICORIC PHARMACEUTICALS INC View history and evidence | $55.04M | 2.51% | 6.73M shares | 3.88% → 2.51%-1.37 pp 0 (0.00%) | Unchanged | ↗▾ |
| 10 | LKFTLAKEFRONT BIOTHERAPEUTIC-ADRSPON ADR View history and evidence | $54.51M | 2.49% | 1.67M shares | 2.77% → 2.49%-0.28 pp 0 (0.00%) | Unchanged | ↗▾ |
Options overlay 2
$13.19M notionalPut and Call positions are separate. Notional is based on underlying securities, not option premium, market value or net exposure. Quantities are underlying shares.
| Security | Put / Call | Underlying shares | Notional | Quantity change | |
|---|---|---|---|---|---|
CGONCG ONCOLOGY INC View history and evidence | Call | 292.80K | $12.16M | +292.80K | ▾ |
XNCRXENCOR INC View history and evidence | Call | 67.50K | $1.03M | +67.50K | ▾ |
2 / 2 options · preview only
Exited positions 11
| Security | Type | Shares out | Value out | Previous filing | This filing |
|---|---|---|---|---|---|
| QURE UNIQURE NV | Non-derivative | -3,988,971 | -$232.84M | SEC filing ↗ | SEC filing ↗ |
| TNGX TANGO THERAPEUTICS INC | Non-derivative | -10,630,736 | -$89.30M | SEC filing ↗ | SEC filing ↗ |
| APLS APELLIS PHARMACEUTICALS INC | Non-derivative | -3,447,156 | -$78.01M | SEC filing ↗ | SEC filing ↗ |
3 / 11 preview exits. Up to 30 exit records are previewed. Exit means absent from the current filing; execution date, price and proceeds are unknown.
Every number has a source.
CIK 1587114 · Period 2025-12-31
Data loaded 2026-09-23 · First reported 2026-02-17
Amendments and versions
{
"amendments_merged": null,
"prior_versions": null,
"cover_table_value": 2204008593
}Take these holdings further.
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